孕早期血清P、HCG和HPL水平变化及与不良妊娠关系  

Changes of the levels of serum progesterone, human chorionic gonadotropin, and human placental lactogen of women during the first trimester of pregnancy and their correlation with adverse pregnancy outcomes

作　　者：李婉萍 雍敏婕 许丽雯 LI Wanping;YONG Minjie;XU Liwen(Dalian Maternal and Child Health Care hospital,Liaoning Province,116021;Yinchuan Maternal and Child Health Care hospital,Ningxia Hui Autonomous Region)

机构地区：[1]大连市妇幼保健院,116021 [2]宁夏回族自治区银川市妇幼保健院

出　　处：《中国计划生育学杂志》2021年第3期552-555,共4页Chinese Journal of Family Planning

摘　　要：目的:分析孕早期血清孕酮(P)、绒毛促性腺激素(HCG)和胎盘生乳素(HPL)水平变化及与不良妊娠关系。方法:回顾性收集本院2017年3月—2019年4月早期不良妊娠89例,包括先兆流产39例、早期妊娠终止21例、异位妊娠29例;同期产前检查正常妊娠孕妇89例为正常组。对比不同孕妇孕6、8周时血清HCG、P、HPL水平及与不良妊娠关系。结果:孕6周和8周时,正常组HCG、P、HPL水平均高于不良妊娠组,且孕6周时不良妊娠组中3项指标水平先兆流产>异位妊娠>早期妊娠终止孕妇,孕8周时正常组与先兆流产孕妇HCG、P、HPL水平均高于孕6周(均P<0.05)。多因素分析,年龄>28岁、既往有流产史、孕次>2次、妊娠期糖尿病,HCG、P、HPL异常为影响孕妇不良妊娠结局独立危险因素(P<0.05)。结论:孕早期妊娠异常者HCG、P、HPL水平均低于正常妊娠者;动态监测孕妇HCG、P、HPL水平,有益于预防不良妊娠结局发生。Objective: To analyze the changes of the levels of serum progesterone(P), human chorionic gonadotropin(HCG), and human placental lactogen(HPL) of women during the first trimester of pregnancy, and to study their correlation with adverse pregnancy outcomes. Methods: 89 pregnant women with adverse pregnancy outcomes in the study group from March 2017 to April 2019 were collected retrospectively, which included 39 cases with threatened abortion in group A, 21 cases with termination of pregnancy during the first trimester of pregnancy in group B, and 29 cases with ectopic pregnancy in group C. In addition, 89 normal pregnant women were selected in control group during the same period. The levels of HCG, P, and HPL of the women during 6 and 8 gestational weeks were compared among these groups. The correlation between the levels of HCG, P, and HPL of the women and their adverse pregnancy outcomes was analyzed. Results: The levels of HCG, P, and HPL of the women in the control group during 6 and 8 gestational weeks were significant higher than those of the women in the study group(P<0.05). In the study group, the levels of HCG, P, and HPL of the women in group A during 6 gestational weeks were the highest, and those of the women in group B were the lowest. The levels of HCG, P, and HPL of the women in group A and in the control group during 8 gestational weeks were significant higher than those during 6 gestational weeks(all P<0.05). Multivariate analysis showed that age over 28 years old, previous history of abortion, pregnancy times >2 times, gestational diabetes mellitus, abnormal levels of HCG, P, and HPL were the independent risk factors of the adverse pregnancy outcomes of pregnant women(P<0.05). Conclusion: The levels of HCG, P, and HPL of the women with abnormal pregnancy during the first trimester of pregnancy are lower than those of the normal pregnant women. Dynamically monitoring the levels of HCG, P, and HPL of the pregnant women can help prevent the occurrence of adverse pregnancy outcomes.

关 键 词：早期不良妊娠 孕酮 绒毛促性腺激素 胎盘生乳素 相关性 

分 类 号：R714.2[医药卫生—妇产科学]