滋肾育胎丸联合来曲唑治疗多囊卵巢综合征对患者血清E2、VEGF水平及早期妊娠影响  

Influence of Zishenyutai pill combined with letrozole for treating women with polycystic ovary syndrome on their levels of E and VEGF

作　　者：李科[1] 陈小芬[1] 李兰[1] 吴斌[1] 周洪贵[1] LI Ke;CHEN Xiaofen;LI Lan;WU Bin;ZHOU Honggui(Affiliated Hospital of North Sichuan Medical College,Sichuan Province,637000)

机构地区：[1]川北医学院附属医院,南充637000

出　　处：《中国计划生育学杂志》2021年第3期556-559,共4页Chinese Journal of Family Planning

基　　金：南充市市级应用技术研究与开发资金项目(16YFZJ0065)。

摘　　要：目的:探究滋肾育胎丸联合来曲唑治疗后多囊卵巢综合征患者血清雌二醇(E2)、血管内皮生长因子(VEGF)水平变化及对早期妊娠影响。方法:选取2018年5月—2019年7月本院妇产科收治的多囊卵巢综合征患者96例,随机数字表法分为观察组52例和对照组44例。两组均采用来曲唑治疗,观察组加用滋肾育胎丸治疗。治疗5d观察两组E2、VEGF水平,子宫内膜厚度和卵泡过度刺激综合征(OHSS)发生率,排卵和妊娠情况以及不良反应。结果:治疗后观察组总有效率(98.1%)高于对照组(84.1%),E2、VEGF水平高于对照组(均P<0.05);两组排卵率、优势卵泡数、妊娠率子宫内膜厚度、OHSS发生率等比较无差异,血小板减少、血红蛋白减少、胃肠道反应总不良反应发生率无差异(均P>0.05)。结论:滋肾育胎丸联合来曲唑可有效提高多囊卵巢综合征患者E2、VEGF水平,改善临床效果,未增加不良反应。Objective:To explore the changes of estradiol(E2)and vascular endothelial growth factor(VEGF)levels of women with polycystic ovary syndrome(PCOS)after treated by Zishenyutai pill combined with letrozole,and to study their influence on the early pregnancy of these women.Methods:From May 2018 to July 2019,96 women with PCOS were enrolled,and were divided in 52 cases in observation group and 44 cases in control group according to the method of random number table.The women in the control group were treated by letrozole alone,and the women in the observation group were treated by letrozole combined with Zishenyutai pill.5 days after treatment,the levels of E2 and VEGF,endometrial thickness,and the incidences of ovarian hyperstimulate syndrome(OHSS),ovulation,pregnancy,and adverse reactions of the women in the two groups were observed.Results:After treatment,the total effective rate(98.1%)of the women in the observation group was significant higher than that(84.1%)of the women in the control group,and the levels of E2 and VEGF of the women in the observation group were significant higher than those of the women in the control group(all P<0.05).There were no significant differences in ovulation rate,number of dominant follicles,pregnancy rate,endometrial thickness,and incidence of OHSS of the women between the two groups(P>0.05).There were no significant differences in the incidences of thrombocytopenia,hemoglobin reduction,and total adverse reactions of gastrointestinal tract of the women between the two groups(P>0.05).Conclusion:Zishenyutai pill combined with letrozole can effectively improve the levels of E2 and VEGF of women with PCOS,and can increase the clinical effect without increasing adverse reactions.

关 键 词：多囊卵巢综合征 来曲唑 滋肾育胎丸 雌二醇 血管内皮生长因子 妊娠 

分 类 号：R711.75[医药卫生—妇产科学]