转化生长因子β1、中性粒细胞/淋巴细胞与妊娠高血压患者母婴预后相关性  

Correlation between transforming growth factorβ1 and neutrophil/lymphocyte of women with pregnancy induced hypertension and the maternal and infant prognosis

作　　者：贾健 杨丹[1] 赵亚宁[1] 郑福利[1] IA Jian;YANG Dan;ZHAO Yaning;ZHENG Fuli(The Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine,Xian,Shaanxi Province,710000)

机构地区：[1]陕西中医药大学第二附属医院,西安710000

出　　处：《中国计划生育学杂志》2021年第3期560-563,567,共5页Chinese Journal of Family Planning

摘　　要：目的:探讨血清转化生长因子β1(TGF-β1)、中性粒细胞/淋巴细胞(NLR)与妊娠期高血压疾病(PIH)患者母婴预后的相关性。方法:回顾性收集2019年1—12月本院收治的PIH患者256例(PIH组),同期行产前检查并分娩的健康孕妇100例为对照组。比较各组间血清TGF-β1、NLR水平及相关性分析。结果:PIH组TGF-β1、中性粒细胞(NeuC)、NLR均高于对照组(P<0.05),淋巴细胞(LymC)两组无差异(P>0.05),子痫前期重度者TGF-β1、NeuC、NLR最高,轻度者次之,妊娠期高血压最低(P<0.05),LymC无差异(P>0.05)。PIH孕妇中,发生不良妊娠结局者血清TGF-β1、NLR水平高于正常结局者,发生新生儿不良结局者血清TGF-β1、NLR水平高于正常新生儿结局者,且随着新生儿不良结局的加重(胎儿生长受限、胎儿窘迫、新生儿窒息、胎死宫内),PIH孕妇血清TGF-β1、NLR水平升高(均P<0.05)。经Pearson相关性分析,PIH孕妇血清TGF-β1、NLR与妊娠不良结局发生、新生儿不良结局发生均呈正相关(P均<0.05)。TGF-β1联合NLR检测诊断敏感度(0.766)和特异度(0.864)高于TGF-β1、NLR单独检测(P均<0.05)。结论:TGF-β1、NLR与PIH孕妇的病情严重程度密切相关,且可能作为预测其母婴不良结局的有效临床指标。Objective:To investigate the relationship between serum transforming growth factorβ1(TGF-β1),neutrophil/lymphocyte of women with pregnancy induced hypertension(PIH)and the maternal and infant prognosis.Methods:From January 2019 to December 2019,256 women with PIH were selected in study group,and 100 normal pregnant women were selected in control group during the same time.The levels of serum TGF-β1 and neutrophil/lymphocyte of the women were compared between the two groups,and the correlation was analyzed.Results:The levels of TGF-β1,neutrophil(Neuc),and neutrophil/lymphocyte of the women in the study group were significant higher than those of the women in the control group(P<0.05),but the lymphocyte(LymC)level had no significant difference between the two groups(P>0.05).The levels of TGF-β1,NEUC,neutrophil/lymphocyte of the women with severe preeclampsia were the highest,followed by those of the women with mild preeclampsia,and those of the women with PIH are the lowest(P<0.05).There was no significant difference in the LymC level among the women with severe preeclampsia,the women with mild preeclampsia,and the women with PIH(P>0.05).The levels of TGF-β1 and neutrophil/lymphocyte of the women with adverse pregnancy outcomes were significant higher than those of the women without adverse pregnancy outcomes.The levels of TGF-β1 and neutrophil/lymphocyte of the women with adverse neonatal outcomes were significant higher than those of the women without adverse neonatal outcomes,and which had increased with the aggravation of adverse neonatal outcomes,such as fetal growth restriction,fetal distress,neonatal asphyxia,and fetal intrauterine death(all P<0.05).Pearson correlation analysis showed that the levels of the serum TGF-β1 and neutrophil/lymphocyte were positively correlated with the occurrence of adverse pregnancy outcomes and adverse neonatal outcomes of pregnant women with PIH(all P<0.05).The sensitivity(0.766)and the specificity(0.864)of TGF-β1 level combined with neutrophil/lymphocyte level for di

关 键 词：妊娠期高血压疾病 转化生长因子Β1 中性粒细胞/淋巴细胞 母婴结局 预测价值 

分 类 号：R714.246[医药卫生—妇产科学]