子宫内膜异位症患者阴道微生物代谢产物分析  

Analysis of correlation between vaginal microbiological metabolites and endometriosis occurrence

作　　者：朱华洁 杨雪慧 ZHU Huajie;YANG Xuehui(Jianggan District People's Hospital of hangzhou City,Zhejiang Province,310016;The Second Hospital of Heilongjiang Province)

机构地区：[1]浙江省杭州市江干区人民医院,310016 [2]黑龙江省第二医院

出　　处：《中国计划生育学杂志》2021年第3期564-567,共4页Chinese Journal of Family Planning

摘　　要：目的:分析子宫内膜异位症(EMS)患者阴道微生物代谢产物的特点及与临床特征关系。方法:选择2017年2月—2020年7月本院治疗的EMS患者(观察组)及同期年龄匹配健康体检女性(对照组)。评估观察组手术分期、痛经程度及血清CA125水平。采用干化学酶法进行阴道微生态功能学检测并比较两组差异,按照手术分期、痛经程度及血清CA125水平分析阴道微生态功能学特点及相关性。结果:观察组过氧化氢(H2O2)阳性率(70.3%)、β-葡萄糖醛酸酶(GUS)阳性率(38.0%)均高于对照组(51.5%、25.4%),且r-AFSⅠ期、Ⅱ期、Ⅲ-Ⅳ期患者H2O2阳性率、GUS阳性率逐渐升高(均P<0.05),LE、NAG及SNA的阳性率两组均无差异(P>0.05)。观察组视觉模拟评分法(VAS)评分≤5分与6~10分比较,血清CA125≤50U/ml与>50U/ml比较,H2O2阳性率、GUS阳性率均未见差异(P>0.05);手术r-AFS分期与H2O2阳性及GUS阳性存在正相关关系(P<0.05),VAS评分、血清CA125与H2O2阳性及GUS阳性无相关性(P>0.05)。结论:EMS发生发展可能与阴道微生态环境失衡有关。Objective:To analyze the characteristics of vaginal microbiological metabolites of women with endometriosis(EMS),and to study its correlation with their clinical features.Methods:The women with EMS were selected in observation group from February 2017 to July 2020,and the healthy women were selected in control group during the same period.The operative stage,dysmenorrhea degree,and serum CA125 level of the women in the observation group were evaluated.Dry chemical enzyme method was used to detect vaginal microecological environment.The difference of vaginal microecological environment detection results of the women was compared between the two groups.The vaginal microecological function characteristics of the women in the observation group and its correlation were analyzed according to their operative stage(r-AFS stage),dysmenorrhea degree,and serum CA125 level.Results:The positive rates of H2O2(70.3%)andβ-glucuronase(GUS,38.0%)of the women in observation group were significant higher than those(51.5%and 25.4%)of the women in control group,and the positive rates of H2O2 and GUS of the women with r-AFS stageⅠ,ⅡandⅢ-Ⅳwere gradually increased(all P<0.05).The positive rates of LE,NAG and SNA of the women had no significant different between the two groups(P>0.05).The positive rates of H2O2 and GUS had no significant different between the women with visual analogue scale(VAS)score≤5 and women with VAS score 6-10,and between the women with serum CA125 level≤50 U/mL and the women with serum CA125 level>50 U/mL(P>0.05).The r-AFS stage of operation was positively correlated with the positivity of H2O2 and GUS(P<0.05),while VAS score and serum CA125 level had no correlation with the positivity of H2O2 and GUS(P>0.05).Conclusion:The imbalance of vaginal microecological environment may be related to the occurrence and development of EMS of women.

关 键 词：子宫内膜异位症 阴道微生态 临床特征 手术分期 

分 类 号：R711.71[医药卫生—妇产科学]