硫酸镁联合胰激肽释放酶治疗重度子痫前期疗效及对孕妇血清NGAL、sFlt-1和sEng影响  

Effect of magnesium sulfate combined with pancreatic kallikrein treatment of severe preeclampsia and its influence on the serum NGAL,sFlt-1 and sEng levels of these women

作　　者：刘红玲[1] 代娟 杨阳 LIU Hongling;DAI Juan;YANG Yang(Cangzhou Central Hospital,Cangzhou,Hebei Province,061001)

机构地区：[1]河北省沧州市中心医院,061001

出　　处：《中国计划生育学杂志》2021年第4期726-729,734,共5页Chinese Journal of Family Planning

摘　　要：目的:探讨硫酸镁联合胰激肽释放酶治疗重度子痫前期(SPE)疗效及对孕妇血清中性粒细胞明胶酶相关脂运蛋白酶(NGAL)、可溶性血管内皮生长因子受体1(sFlt-1)和可溶性内皮因子(sEng)水平的影响。方法:选取2016年12月—2019年12月本院收治的SPE患者85例,随机数字法分为对照组(n=42)和观察组(n=43),对照组给予硫酸镁治疗,观察组给予硫酸镁联合胰激肽释放酶治疗,比较两组临床疗效、血压水平、子宫动脉和脐动脉血流状态、血清NGAL、sFlt-1、sEng水平、炎症因子[白细胞介素-10(IL-10)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]及分娩结局。结果:观察组治疗有效率(88.4%)高于对照组(64.3%)(P<0.05);治疗后观察组SBP、DBP、MAP,以及脐动脉和子宫动脉的PI、S/D均低于对照组,血清NGAL、sFlt-1、sEng水平低于对照组,血清IL-6、TNF-α水平低于对照组,IL-10高于对照组,分娩结局优于对照组(均P<0.05)。结论:硫酸镁联合胰激肽释放酶治疗SPE疗效显著,可稳定血压水平,降低血管阻力和血清NGAL、sFlt-1、sEng、IL-4、IL-6水平,并改善分娩结局。Objective: To investigate the effect of magnesium sulfate combined with pancreatic kallikrein for treating pregnant women with severe preeclampsia(SPE), and to study its influence on the levels of serum neutrophil gelatinase-associated lipocalin(NGAL), soluble vascular endothelial growth factor receptor 1(sFlt-1), and soluble endothelial factor(sEng) of these women. Methods: 85 women with SPE were selected and were divided into control group(n=42) and observation group(n=43) by the random number method between December 2016 and December 2019. The women in the control group were treated with magnesium sulfate, and the women in the observation group were treated with magnesium sulfate combined with pancreatic kallikrein. The clinical effect, blood pressure, uterine artery and umbilical artery blood flow, serum NGAL, sFlt-1 and sEng levels, the levels of inflammatory factors [interleukin-10(IL-10), interleukin-6(IL-6), tumor necrosis factor-α(TNF-α)], and delivery outcomes of the women were compared between the two groups. Results: The effective rate of the women in the observation group(88.4%) was significant higher than that(64.3%) of the women in the control group(P<0.05). After treatment, the values of SBP, DBP and MAP, the values of PI and S/D of umbilical artery and uterine artery, serum Ngal, sflt-1, sEng, IL-6, and TNF-αlevels of the women in the observation group were significant lower than those of the women in the control group, but the IL-10 level of the women in the observation group was significant higher(all P<0.05). The delivery outcomes of the women in the observation group were significant better than those of the women in the control group(P<0.05). Conclusion: Magnesium sulfate combined with pancreatic kallikrein for treating pregnant women with SPE is markedly effective, which can stabilize blood pressure, reduce vascular resistance, decrease serum NGAL, sFlt-1, sEng, IL-4 and IL-6 levels, and improve delivery outcomes.

关 键 词：重度子痫前期 硫酸镁 胰激肽释放酶 中性粒细胞明胶酶相关脂运蛋白酶 可溶性血管内皮生长因子受体1 可溶性内皮因子 

分 类 号：R714.244[医药卫生—妇产科学]