子宫动脉血流参数联合血清FFA预测早发型子痫前期合并胎儿宫内生长受限  

Value of uterine artery blood flow parameters combined with serum FFA for predicting of early onset preeclampsia with intrauterine growth restriction

作　　者：门晓玉[1] 黄小艳[1] 陈珂珂[1] 张霞[1] MEN Xiaoyu;HUANG Xiaoyan;CHEN Keke;ZHANG Xia(The First People's Hospital of Shangqiu,Henan Province,476100)

机构地区：[1]河南省商丘市第一人民医院,476100

出　　处：《中国计划生育学杂志》2021年第4期802-805,共4页Chinese Journal of Family Planning

摘　　要：目的:分析子宫动脉血流参数联合血清游离脂肪酸(FFA)对早发型子痫前期(EOPE)合并胎儿生长受限(FGR)的预测价值。方法:选取2017年1月—2019年9月本院收治的EOPE孕妇296例,按照是否发生FGR分为EOPE组与合并FGR组。比较两组血流流速(S/D)、阻力指数(RI)、搏动指数(PI)及血清FFA值,分析血清FFA与S/D、RI、PI的相关性,探讨FFA联合子宫动脉参数对EOPE合并FGR的预测价值。结果:合并FGR组血清FFA值(0.78±0.20 mmol/ml)高于EOPE组(0.65±0.18 mmol/ml),S/D(3.75±0.98)、RI(0.73±0.20)、PI(1.02±0.24)高于EOPE组(P均<0.05)。血清FFA值与S/D、RI、PI值呈正相关(r=0.306、0.686、0.577,P<0.05)。ROC曲线分析,血清FFA值与子宫动脉血流参数S/D、RI、PI值对EOPE合并FGR具有预测效能,FFA、RI的预测效能最佳。FFA+S/D、FFA+PI、FFA+RI对EOPE合并FGR具有预测效能,FFA+RI的预测效能最佳(AUC=0.906,敏感性78.7%、特异性84.3%)。结论:血清FFA联合子宫动脉血流RI值预测EOPE合并FGR具有理想的效能。Objective: To analyze the value of uterine artery blood flow parameters combined with serum free fatty acid(FFA) for predicting the pregnant women with early onset preeclampsia(EOPE) and intrauterine growth restriction(FGR). Methods: 296 pregnant women with EOPE were selected as research objects and were divided into group A(women with EOPE only) and group B(women with EOPE and FGR) according to the occurrence of FGR from January 2017 to September 2019. The values of S/D, RI, and PI of uterine artery, and serum FFA level of the women were compared between the two groups. The correlation between serum FFA level and the values of S/D, RI, and PI of uterine artery was analyzed. The value of FFA level combined with uterine artery parameters for predicting EOPE and FGR was discussed. Results: The serum FFA level of the women in group B(0.78±0.20 mmol/mL) was significant higher than that(0.65±0.18 mmol/mL) of the women in group A, and the value of S/D(3.75±0.98), RI(0.73±0.20) and PI(1.02±0.24) of the women in group B were also significant higher than those of the women in group A(all P<0.05). Serum FFA level was positively correlated with S/D, RI and PI values(r=0.306, 0.686, 0.577, P<0.05). ROC curve analysis showed that serum FFA value and uterine artery blood flow parameters(S/D, RI and PI values) had effect for predicting EOPE and FGR. The FFA level combined with S/D, the FFA level combined with PI value, and the FFA level combined with RI value all had effect for predicting EOPE and FGR, among them, the FFA level combined with RI value had the best predictive efficacy, which’s AUC, sensitivity, the specificity were 0.906, 78.7, and 84.3%, respectively. Conclusion: The serum FFA level combined with uterine artery RI value has ideal efficacy for predicting EOPE and FGR.

关 键 词：早发型子痫前期 胎儿生长受限 超声 子宫动脉血流参数 游离脂肪酸 预测价值 

分 类 号：R714.244[医药卫生—妇产科学]