G蛋白偶联受体在肥大细胞激活中的作用研究进展  

Research Progress on the Role of G Protein-coupled Receptors in Mast Cell Activation

作　　者：魏钰倩 苏文星 季江[1] 王娟娟 赵莹 丁瑜洁[1] 单芳芳 焦晴晴[2] WEI Yuqian;SU Wenxing;JI Jiang;WANG Juanjuan;ZHAO Ying;DING Yujie;SHAN Fangfang;JIAO Qingqing(Department of Dermatology,the Second Affiliated Hospital of Soochow University,Suzhou 215004,China;Department of Dermatology,the First Affiliated Hospital of Soochow University,Suzhou 215004,China)

机构地区：[1]苏州大学附属第二医院皮肤性病科,江苏苏州2150042 [2]苏州大学附属第一医院皮肤性病科,江苏苏州2150042

出　　处：《中国皮肤性病学杂志》2021年第5期565-569,共5页The Chinese Journal of Dermatovenereology

基　　金：国家自然科学基金青年项目(81803127);苏州市民生科技项目(SS201643);苏州市科技发展计划(SYS2018056)。

摘　　要：G蛋白偶联受体(GPCRs)是人体内最大的表面受体超家族,能够识别周围环境中特定的化学物质并与之结合。肥大细胞(MCs)是变态反应中重要的效应细胞,活化后通过释放细胞因子和炎症介质在变态反应中起关键作用,参与多种疾病的炎症进程。MCs的激活包括IgE依赖性和非依赖性两种主要途径,而GPCRs对这两个途径介导的MCs活化都具有调节作用。本文就主要的GPCRs在肥大细胞激活中的作用作一综述。G protein-coupled receptors(GPCRs)are the largest superfamily of surface receptors in the human body,which have the ability to recognize and bind to specific chemicals in the surrounding environment.Mast cells(MCs)are important effector cells in allergies.After activation,they play a key role in allergies by releasing cytokines and inflammatory mediators,and participate in the inflammatory process of various diseases.The activation of MCs includes two major pathways,IgE-dependent and IgE-independent,and GPCRs can regulate the activation of MCs mediated by both pathways.This article reviews the role of major GPCRs in mast cell activation.

关 键 词：肥大细胞 G蛋白偶联受体 IgE FcεRI 过敏 

分 类 号：R346[医药卫生—基础医学]