褪黑素调节肺动脉高压的作用与机制研究进展  

Research progress of melatonin on pulmonary hypertension

作　　者：王睿 潘进进[1] 李华 袁予辉[1] WANG Rui;PAN Jinjin;LI Hua;YUAN Yuhui(Institute of Cancer Stem Cell,Dalian Medical University University,Dalian 116044,Liaoning,China;Department of Hematology,the Second Hospital of Dalian Medical University,Dalian 116027,Liaoning,China;College of Pharmacy,Dalian Medical University,Dalian 116044,Liaoning,China)

机构地区：[1]大连医科大学肿瘤干细胞研究院,辽宁大连116044 [2]大连医科大学附属第二医院血液科,辽宁大连116027 [3]大连医科大学药学院,辽宁大连116044

出　　处：《中国临床药理学与治疗学》2021年第4期444-448,共5页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家自然科学基金面上项目(81472492)。

摘　　要：肺动脉高压是一种严重的进行性心肺功能障碍疾病,以代偿性肺动脉压力升高和持续进展性肺血管阻力升高为特征,最终导致右心衰竭,死亡率高,尚无治愈手段。褪黑素是一种主要由松果体腺分泌的小分子激素,具有多器官保护作用,其抑制肺动脉血管重构,降低肺动脉压力的作用近年来备受学者广泛关注。本文针对褪黑素在肺动脉高压中的作用研究进展作一综述。Pulmonary hypertension is a severe disease with a wide spectrum of underlying etiologies,which was characterized by increased pulmonary arterial pressure and pulmonary vascular resistance,and eventually leads to right heart dysfunction and even death with a high mortality rate.Melatonin,as a neuroendocrine hormone,is produced primarily by the pineal gland.Melatonin,a pleotropic molecule,plays a key role in the pathophysiology of various cardiovascular diseases.The effects of melatonin which can attenuate pulmonary vascular remodeling and pulmonary artery pressure have been widely concerned by researchers in recent years.This review summarized the progress of melatonin on pulmonary hypertension.

关 键 词：褪黑素 肺动脉高压 抗炎 抗氧化 

分 类 号：R563[医药卫生—呼吸系统]