液氮冷冻棉签法治疗皮肤疣的应用研究  

Application of liquid nitrogen frozen cotton swab in the treatment of skin warts

作　　者：陆艳 莫伟英 王艳红 李洁清 LU Yan;MO Wei-ying;WANG Yan-hong(Department of Dermatology,Qingyuan Chronic Disease Prevention and Treatment Hospital,Qingyuan 511500,China)

机构地区：[1]清远市慢性病防治医院皮肤科,511500

出　　处：《中国实用医药》2021年第10期24-27,共4页China Practical Medicine

摘　　要：目的观察液氮冷冻棉签法治疗皮肤疣的临床疗效。方法 64例(271个疣体)皮肤疣患者,采用随机数字表法分为A组(168个疣体, 32例)和B组(103个疣体, 32例)。两组均采用液氮冷冻棉签法治疗, A组冷冻范围超出疣体1 mm, B组冷冻范围超出疣体2 mm。分析比较两组治疗效果、治愈次数、并发症发生率及复发率。结果两组治愈率比较差异无统计学意义(P>0.05)。B组治愈次数≤3次的疣体占比为87.69%,高于A组的68.63%,差异有统计学意义(P<0.05)。B组水疱/血疱发生率75.73%及视觉模拟评分法(VAS)评分(6.46±2.92)分均高于A组的52.98%、(5.25±2.29)分,差异有统计学意义(P<0.05)。B组复发率为13.85%,低于A组的35.29%,差异有统计学意义(P<0.05)。结论液氮冷冻棉签法治疗皮肤疣,冷冻范围应大于病灶区域,白霜超出疣体1 mm与2 mm均对皮肤疣有效,且以超出疣体2 mm的冷冻范围复发率低、效果最佳。虽然增加冷冻范围并发症增多,但患者均能耐受。Objective To observe the clinical efficacy of liquid nitrogen frozen cotton swab in the treatment of skin warts. Methods A total of 64 skin warts patients(271 warts) were divided into group A(168 warts, 32 cases) and group B(103 warts, 32 cases) according to random numerical table. Both groups were treated with liquid nitrogen frozen cotton swabs. The freezing range of group A was 1 mm beyond the wart, and the freezing range of group B was 2 mm beyond the wart. The therapeutic effect, number of cure, incidence of complication and recurrence rate were analyzed and compared between the two groups. Results There was no statistically significant difference in cure rate between the two groups(P>0.05). The proportion of warts cured ≤3 times in group B was 87.69%, which was higher than 68.63% in group A, and the difference was statistically significant(P<0.05). The incidence of blisters/blood blisters 75.73% and visual analogue scale(VAS) score(6.46± 2.92) points of group B were all higher than 52.98% and(5.25±2.29) points of group A, and the difference was statistically significant(P<0.05). The recurrence rate of group B was 13.85%, which was lower than 35.29% of group A, and the difference was statistically significant(P<0.05). Conclusion The freezing range of liquid nitrogen freezing cotton swab method to treat skin warts should be larger than the lesion area. Both 1 mm and 2 mm beyond the wart body are effective for skin warts, and the freezing range beyond the wart body 2 mm has a low recurrence rate and the best effect. Although increasing in freezing range will increase complications, patients can tolerate it.

关 键 词：液氮冷冻棉签法 皮肤疣 治愈率 

分 类 号：R752.5[医药卫生—皮肤病学与性病学]