医用金属材料在骨科应用中的生物功能化  

Bio-functionalization of medical metal materials in orthopedic application

作　　者：李珊 刘超 晏怡果[1] Li Shan;Liu Chao;Yan Yiguo(Department of Spine Surgery,The First Affiliated Hospital of University of South China,Hengyang 421001,Hunan Province,China)

机构地区：[1]南华大学附属第一医院脊柱外科,湖南省衡阳市421001

出　　处：《中国组织工程研究》2021年第34期5523-5529,共7页Chinese Journal of Tissue Engineering Research

基　　金：湖南省脊柱微创临床医学研究中心(2017SK4004),项目负责人:晏怡果。

摘　　要：背景:目前骨科医用金属材料经过多年的临床应用仍然存在许多问题,不仅面临着材料植入体内后的自体免疫反应、弹性模量与人体骨不相匹配、骨与界面不融合等问题,还由于金属腐蚀和磨损直接或间接造成的影响。目的:对医用金属材料在骨科应用中的生物功能化进行概述。方法:由第一作者应用计算机检索PubMed、CNKI、Web of Science数据库中的相关文献,英文检索词为“Orthopedics、metallic material、bio-functionalization”,中文检索词为“骨科医用金属,3D打印技术,生物功能化,表面改性,材料表面涂层”,最终纳入61篇文献进行综述。结果与结论:医用金属材料是最早运用在骨科的材料,最初对医用金属材料的研究都聚焦在金属材料本质上,随着对骨替代材料的不断研究,材料属性正在从生物惰性向生物活性和生物功能化发展。在不改变本体材料性能的前提下,采用表面物理改性、化学改性及表面生物改性进行金属材料生物功能的有机耦合,进一步实现医用金属材料的生物功能化,使骨科医用金属材料不仅具有良好的力学性能和生物相容性,而且还具有良好的生物活性、抗炎性能和骨诱导性,这些多功能的协同作用将成为临床应用新领域,也为开发生物医学金属的新功能指明方向。BACKGROUND:There are still many problems in orthopedic medical metal materials after many years of clinical application,including autoimmune reaction,the mismatch of elastic modulus and human bone,the non-fusion of bone and interface after implantation,and the direct or indirect impact of metal corrosion and wear.OBJECTIVE:To summarize the bio-functionalization of medical metal materials in orthopedic applications.METHODS:The first author used computer to search the relevant literature of PubMed,CNKI,and Web of Science database.The English search terms were“orthopedics,metallic material,bio-functionalization”,and the Chinese search terms were“orthopedic medical metals,3D printing technology,biofunctionalization,surface modification,material surface coating”.Finally,61 articles were included for review.RESULTS AND CONCLUSION:Medical metal materials are the earliest materials used in orthopedics.The initial research on medical metal materials focused on the nature of metal materials.With the continuous research on bone substitute materials,the properties of materials are developing from biological inertness to biological activity and biological functionalization.Under the premise of not changing the properties of the body material,the organic coupling of the biological functions of metal materials was carried out by using surface physical modification,chemical modification and surface biological modification to further realize the bio-functionalization of medical metal materials,so that orthopedic medical metal materials not only have good mechanical properties and biocompatibility,as well as good biological activity,anti-inflammatory properties and osteoinductive properties.These multi-functional synergistic effects will become a new field of clinical application and also point out the direction for the development of new functions of biomedical metals.

关 键 词：骨科 医用金属材料 表面改性 生物功能化 3D打印技术 材料表面涂层 

分 类 号：R459.9[医药卫生—治疗学] R318.08[医药卫生—临床医学]