代谢调控蛋白A调控革兰阳性菌代谢与毒力偶联的研究进展  

Progress of catabolite control protein A in the regulation of metabolism and virulence of Gram-positive bacteria

作　　者：杨紫瑜 秦娟秀[1] 李敏[1] 刘倩[1] YANG Zi-yu;QIN Juan-xiu;LI Min;LIU Qian(Department of Laboratory Medicine,Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China)

机构地区：[1]上海交通大学医学院附属仁济医院检验科,上海200127

出　　处：《上海交通大学学报（医学版）》2021年第4期535-539,共5页Journal of Shanghai Jiao tong University:Medical Science

基　　金：国家自然科学基金(81772139);上海交通大学医学院高水平地方高校创新团队(SSMU-ZLCX20180701);上海交通大学医学院附属仁济医院培育基金(PYIII-17-001)。

摘　　要：代谢调控蛋白A(catabolite control protein A,CcpA)是革兰阳性菌重要的多效调节因子,在磷酸烯醇丙酮酸依赖的磷酸转移酶系统辅助下,能与靶基因上的特异性DNA序列——代谢反应元件结合,促进或阻遏靶基因表达,从而调控细菌的生理过程和毒力。CcpA通过介导微生物碳分解代谢物阻遏效应,控制细菌摄取与利用外界环境中营养物质,保障其高效利用能源。CcpA通过直接或间接调控细菌的代谢过程和毒力基因表达,将细菌的代谢与毒力偶联。该文介绍了CcpA的作用机制及其对细菌多种代谢途径和致病性调控的研究进展。Catabolite control protein A(CcpA)is an important pleiotropic regulator in Gram-positive bacteria.With the assistance of the phosphoenolpyruvate-dependent carbohydrate phosphotransferase system,CcpA undergoes a conformational change and interacts with catabolite responsive element,a specific DNA sequence on the target gene,activating or repressing expression of the target gene,thereby controlling the physiological processes and virulence of bacteria.CcpA mediates the carbon catabolite repression effect of microorganisms to control the uptake and utilization of environmental nutrients,ensuring the efficient use of energy by bacteria.CcpA regulates bacterial metabolism and virulence gene expression directly or indirectly,coupling the metabolism and virulence of bacteria.This review describes the mechanism of CcpA function,and summarizes the research progress of CcpA in regulating multiple metabolic pathways and pathogenicity of bacteria.

关 键 词：代谢调控蛋白A(CcpA) 碳分解代谢物阻遏效应(CCR) 代谢 毒力 

分 类 号：R378[医药卫生—病原生物学]