载脂蛋白与昆虫先天免疫  

Apolipoprotein and Innate Immunity of Insects

作　　者：赵诣 孙霞[1] 李木旺[1] 秦笙[2] Zhao Yi;Sun Xia;Li Muwang;Qin Sheng(School of Biotechnology,Jiangsu University of Science and Technology,Zhenjiang Jiangsu 212100,China;Sericultural Research Institute,Chinese Academy of Agricultural Sciences,Zhenjiang Jiangsu 212100,China)

机构地区：[1]江苏科技大学生物物技术学院,江苏镇江212100 [2]中国农业科学院蚕业研究所,江苏镇江212100

出　　处：《蚕业科学》2020年第6期777-783,共7页ACTA SERICOLOGICA SINICA

基　　金：国家自然科学基金青年科学基金项目(31601895);江苏省研究生科研与实践创新计划项目(KYCX19_1657)。

摘　　要：昆虫脂蛋白是一种非共价组装体,由脂质和用作脂质运输工具的蛋白质组装而成。脂蛋白的蛋白质部分即载脂蛋白(apolipoprotein,apoLp),载脂蛋白在昆虫中除了运输脂质、调节全身脂质代谢等功能外,还在先天免疫中起着重要的作用,其在先天免疫中的功能在果蝇(Drosophila melanogaster)、家蚕(Bombyx mori)、蓖麻蚕(Philosamia cynthia ricini)和柞蚕(Antherea pernyi)等昆虫中得到了广泛的研究。在免疫应答中,载脂蛋白充当病原体识别受体,并参与到昆虫的体液免疫和细胞免疫反应中,apoLp-Ⅰ、apoLp-Ⅱ和apoLp-Ⅲ在应对病原体的协同防御中共同发挥了重要作用。本文重点概括了载脂蛋白在昆虫先天免疫中的研究进展,从病原体识别受体、体液免疫、细胞免疫、凝集作用及害虫防治等方面对载脂蛋白在昆虫先天免疫中的作用进行了总结,为相关方向的研究提供借鉴。Insect lipoprotein is a noncovalent assembly of lipids and proteins used as lipid transporters.The protein in lipoprotein is apolipoprotein(apoLp).Apart from its functions in lipid transport and regulation of systemic lipid metabolism,apoLp plays an important role in innate immunity of insects,which has been extensively studied in Drosophila melanogaster,Bombyx mori,Philosamia cynthia ricini and Antherea pernyi.Moreover,apolipoprotein as pathogen recognition receptor in the immune response participates in humoral and cellular immune responses of insects,and apoLp-Ⅰ,apoLp-Ⅱand apoLp-Ⅲhave played important roles in cooperating the defense against pathogens.In this study,research progress of apolipoprotein in insect innate immunity was highlighted,and the role of apolipoprotein as pathogen recognition receptor,and its function in humoral immunity,cellular immunity,agglutination and pest control was summarized,which could provide valuable reference for relevant research.

关 键 词：昆虫 载脂蛋白 先天免疫 

分 类 号：Q966[生物学—昆虫学] Q939.91