阿替普酶辅助微创术在脑出血治疗中的应用及有效性研究  

Application and effectiveness of alteplase-assisted minimally invasive surgery in the treatment of cerebral hemorrhage

作　　者：王永照 WANG Yong-zhao(Department of Neurosurgery,Longkou People’s Hospital,Longkou 265700,China)

机构地区：[1]龙口市人民医院神经外科,265700

出　　处：《中国实用医药》2021年第11期7-9,共3页China Practical Medicine

摘　　要：目的探索阿替普酶辅助微创术在脑出血治疗中的应用及有效性。方法100例脑出血患者,依照奇偶数法分为对照组和实验组,每组50例。对照组采用保守治疗方法,实验组在对照组治疗基础上增加阿替普酶辅助微创术治疗。比较两组患者治疗效果,不同时间段(手术前、术后1 d、术后3 d、术后7 d)血肿量、颅内压,手术前后美国国立卫生研究院卒中量表(NIHSS)评分以及日常生活活动能力(ADL)评分。结果实验组患者治疗总有效率为88.00%,高于对照组的72.00%,差异具有统计学意义(P<0.05)。术后1、3、7 d,两组患者血肿量均少于本组手术前,且实验组明显少于对照组,差异具有统计学意义(P<0.05)。术后1、3、7 d,两组患者颅内压均低于本组手术前,且实验组明显低于对照组,差异具有统计学意义(P<0.05)。手术后,两组患者NIHSS评分均低于本组手术前,且实验组NIHSS评分(1.60±0.85)分低于对照组的(3.20±1.10)分,差异具有统计学意义(P<0.05)。手术后,两组患者ADL评分均高于本组手术前,且实验组ADL评分(76.95±11.70)分高于对照组的(50.85±12.50)分,差异具有统计学意义(P<0.05)。结论阿替普酶辅助微创术治疗脑出血患者,能够有效减少血肿量,降低颅内压以及术后NIHSS评分,提高临床治疗效果,改善术后生活质量,效果显著。Objective To discuss the application and effectiveness of alteplase-assisted minimally invasive surgery in the treatment of cerebral hemorrhage. Methods A total of 100 patients with cerebral hemorrhage were divided into control group and experimental group according to odd-even number method, with 50 cases in each group. The control group received conservative treatment, and the experimental group received alteplase-assisted minimally invasive surgery based on the control group. The therapeutic effect, hematoma volume and intracranial pressure in different time periods(before operation, 1 d after operation, 3 d after operation, 7 d after operation), National Institutes of Health stroke scale(NIHSS) score and activities of daily living(ADL) score before and after operation were compared between the two groups. Results The total effective rate of treatment of the experimental group was 88.00%, which was higher than 72.00% of the control group, and the difference was statistically significant(P<0.05). 1, 3 and 7 d after operation, the hematoma volume of the two groups were less than those before operation, and the experimental group was obviously less than the control group, and the difference was statistically significant(P<0.05). 1, 3 and 7 d after operation, the intracranial pressure of the two groups were lower than those before operation, and the experimental group was obviously lower than the control group, and the difference was statistically significant(P<0.05). After operation, the NIHSS score of the two groups were lower than those before operation, and NIHSS score(1.60±0.85) points of the experimental group was lower than(3.20±1.10) points of the control group, and the difference was statistically significant(P<0.05). After operation, the ADL score of the two groups were higher than those before operation, and ADL score(76.95±11.70) points of the experimental group was higher than(50.85±12.50) points of the control group, and the difference was statistically significant(P<0.05). Conclusion Alteplase-a

关 键 词：脑出血 阿替普酶 辅助 微创术 应用 有效性 

分 类 号：R651.1[医药卫生—外科学]