血清免疫球蛋白及外周血T淋巴细胞亚群检验在小儿肺炎支原体感染治疗中的应用效果分析  

Analysis of the practical effect of serum immunoglobulin and peripheral blood T lymphocyte subsets test in the treatment of children with Mycoplasma pneumoniae infection

作　　者：胡成侠 范金斌 郝庭媛 HU Cheng-xia;FAN Jin-bin;HAO Ting-yuan(Department of Clinical Laboratory,Suqian Hospital of Traditional Chinese Medicine,Suqian 223800,China)

机构地区：[1]江苏省宿迁市中医院检验科,223800

出　　处：《中国实用医药》2021年第11期47-49,共3页China Practical Medicine

摘　　要：目的分析血清免疫球蛋白及外周血T淋巴细胞亚群在小儿肺炎支原体感染治疗中的应用效果。方法选取112例肺炎支原体感染患儿作为观察组,另选取111例健康儿童作为对照组。两组均实施血清免疫球蛋白及外周血T淋巴细胞亚群指标检验,对比两组血清免疫球蛋白指标及外周血T淋巴细胞亚群指标。结果观察组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平均低于对照组, CD8^(+)水平高于对照组,差异有统计学意义(P<0.05)。观察组免疫球蛋白M(IgM)(1.96±0.57)g/L高于对照组的(1.01±0.12)g/L,免疫球蛋白A(IgA)(1.05±0.52)g/L、免疫球蛋白G(IgG)(9.92±0.39)g/L均低于对照组的(2.25±0.12)、(10.59±0.48)g/L,差异有统计学意义(P<0.05)。结论肺炎支原体感染患儿的机体免疫力显著降低,血清免疫球蛋白及外周血的T淋巴细胞亚群指标会发生明显改变,通过测定上述指标对患儿的病情程度诊断及临床治疗有一定指导意义,应在治疗中适当加入一定量调节免疫功能的药物,以促进的治疗效果。Objective To analyze the practical effect of serum immunoglobulin and peripheral blood T lymphocyte subsets test in the treatment of children with Mycoplasma pneumoniae infection.Methods There were 112 children infected with Mycoplasma pneumoniae selected as the observation group,and another 111 healthy children as the control group.The serum immunoglobulin and peripheral blood T lymphocyte subsets were tested in both groups.The serum immunoglobulin indicators and peripheral blood T lymphocyte subsets indicators were compared between the two groups.Results The levels of CD3^(+),CD4^(+),CD4^(+)/CD8^(+)of the observation group were lower than those of the control group,and CD8^(+)level was higher than that of the control group,and the difference was statistically significant(P<0.05).The immunoglobulin M(IgM)level(1.96±0.57)g/L of the observation group was higher than(1.01±0.12)g/L of the control group,and immunoglobulin A(IgA)level(1.05±0.52)g/L and immunoglobulin G(IgG)level(9.92±0.39)g/L were lower than(2.25±0.12)and(10.59±0.48)g/L of the control group.All the difference was statistically significant(P<0.05).Conclusion For children infected with Mycoplasma pneumoniae,the immunity of their body will decrease significantly,and the corresponding indicators of serum immunoglobulin and peripheral blood T lymphocyte subsets will change abnormally.The determination of the above indicators has certain guiding significance for the diagnosis and clinical treatment of children’s condition.A certain amount of drugs that regulate immune function should be added to the treatment to promote the treatment effect.

关 键 词：血清免疫球蛋白 外周血T淋巴细胞亚群 小儿肺炎支原体感染 

分 类 号：R725.6[医药卫生—儿科]