应用CorVis ST评估不同屈光状态儿童的角膜生物力学特性  

Corneal visualization Scheimpflug technology evaluates corneal biomechanical properties in children with different refractive states

作　　者：李芳 钟兴武[1] 杨军[1] 龙登虹 林尤青 LI Fang;ZHONG Xingwu;YANG Jun;LONG Denghong;LIN Youqing(Hainan Eye Hospital,Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-sen University,Haikou,Hainan Province,570311,China)

机构地区：[1]中山大学中山眼科中心海南眼科医院(海南省眼科医院),海南省眼科学重点实验室,海口570311

出　　处：《第三军医大学学报》2021年第8期766-770,F0003,共6页Journal of Third Military Medical University

基　　金：海南省自然科学基金(CXTD011,817364)。

摘　　要：目的应用可视化角膜生物力学分析仪评估近视、远视、正视儿童的角膜生物力学特性。方法选取2019年8月至2020年1月就诊于本院近视、远视、正视的儿童123例(191眼),利用可视化角膜生物力学分析仪、Lenstar 900生物测量仪分别测量角膜生物力学参数、眼轴、角膜曲率等,应用单因素线性相关分析及多因素线性回归分析年龄、等效球镜、眼轴长度、角膜厚度、平均角膜曲率等对角膜生物力学特性的影响。结果经多因素线性回归分析,等效球镜与第1次压平时间(P=0.004)呈正相关关系;眼轴与第1次压平长度(P=0.017)、最大压陷时的反向曲率半径(P=0.02)呈正相关关系,与第2次压平时的变形幅度(P<0.001)呈负相关关系;中央角膜厚度与第1次压平长度(P<0.001)、第1次压平时的变形幅度(P=0.005)、产生最大压陷的时间(P=0.004)呈正相关关系,与第1次压平时间(P=0.041)呈负相关关系。结论儿童的角膜生物力学特性可能与其屈光状态相关,较高度数的近视儿童的角膜粘弹性可能较低。Objective To evaluate the corneal biomechanical parameters in myopic,hypermetropic and emmetropic eyes using corneal visualization Scheimpflug technology(CorVis ST).Methods A total of 123 children having 191 myopic,hypermetropic and emmetropic eyes admitted to our hospital from August 2019 to January 2020 were enrolled in this study.Corneal biomechanical parameters,axial length(AL)and corneal curvature were measured using CorVis ST and Lenstar 900 respectively.Univariate linear correlation analysis and multivariate linear regression analysis were used to assess the impacts of age,spherical equivalent(SE),AL,central corneal thickness(CCT)and mean corneal curvature on corneal biomechanical parameters.Results Multivariate linear regression analysis indicated that SE was positively correlated with time at first applanation(A1 T,P=0.004);AL was positively correlated with A1 T(P=0.017)and radius of reverse curvature at the time of highest concavity(HCR,P=0.02),but negatively with deformation amplitude at second applanation(A2 DA,P<0.001);CCT was positively correlated with length at first applanation(A1 L,P<0.001),A1 DA(P=0.005),time of highest concavity(P=0.004),but negatively with A1 T(P=0.041).Conclusion The biomechanical parameters of children may be related with their refractive states.Higher myopic eyes tend to have lower corneal elasticity.

关 键 词：可视化角膜生物力学分析仪 角膜生物力学特性 近视 远视 

分 类 号：R318.01[医药卫生—生物医学工程] R339.141[医药卫生—基础医学]