盐酸二甲双胍联合格列本脲治疗妊娠期糖尿病对孕妇血清VEGF、APN、Hcy影响  

Effects of metformin hydrochloride combined with glibenclamide for treating pregnant women with gestational diabetes mellitus on their serum levels of VEGF,APN,and Hcy

作　　者：张晨昕[1] 杨珊 ZHANG Chenxin;YANG Shan(Wangdingdi Hospital, Nankai District, Tianjin, 300380;Tian Jin Nankai Dislrict Shuige Hospital)

机构地区：[1]天津市南开区王顶堤医院,300380 [2]天津市南开区水阁医院

出　　处：《中国计划生育学杂志》2021年第2期288-291,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨盐酸二甲双胍联合格列本脲治疗妊娠期糖尿病对孕妇血管内皮生长因子(VEGF)、脂联素(APN)、同型半胱氨酸(Hcy)水平的影响。方法:选择天津市南开区水阁医院2018年6月—2019年5月收治的妊娠期糖尿病孕妇80例,数字法随机分为对照组和观察组各40例,对照组接受盐酸二甲双胍单独治疗,观察组接受盐酸二甲双胍联合合格列本脲治疗。比较两组治疗前后血糖、血脂、血清VEGF、APN和Hcy水平。结果:治疗后观察组血糖及24h血糖、糖化血红蛋白、总胆固醇、三酰甘油、低密度脂蛋白、VEGF和Hcy水平均低于对照组,高密度脂蛋白和APN水平均高于对照组(均P<0.05)。结论:盐酸二甲双胍联合格列本脲治疗妊娠期糖尿病能够有效改善孕妇的血糖、血脂、血清VEGF、APN、Hcy水平,具有良好的治疗效果。Objective:To investigate the effects of metformin hydrochloride combined with glibenclamide for treating pregnant women with gestational diabetes mellitus(GDM)on their serum levels of VEGF,APN,and Hcy.Methods:80 pregnant women with GDM were enrolled and were randomly divided into control group and observation group(40 cases in each group)from June 20 to May 2019.The women in the control group had received metformin hydrochloride alone,and the women in the observation group had received metformin hydrochloride combined with glibenclamide.The levels of blood glucose,blood lipids,vascular endothelial growth factor(VEGF),adiponectin(APN),and homocysteine(Hcy)of the women before and after treatment were compared between the two groups.Results:There were no statistically significant different in the levels of blood glucose,blood lipid,VEGF,APN,and Hcy of the women between two groups(P>0.05).After treatment,the levels of FBG,24PG,HbA1c,TC,TG,LDL-C,VEGF,and Hcy of women in the observation group were significant lower than those of women in the control group(P<0.05),but the levels of HDL-C and APN of women in the observation group were significant higher(all P<0.05).Conclusion:Metformin hydrochloride combined with glibenclamide for treating pregnant women with GDM can effectively improve their levels of blood glucose,blood lipids,serum VEGF,APN and Hcy,which has good therapeutic effect.

关 键 词：妊娠期糖尿病 盐酸二甲双胍 格列本脲 血清血管内皮生长因子 脂联素 同型半胱氨酸 

分 类 号：R58[医药卫生—内分泌]