尿β2-MG、KIM-1、Ang-1联合检测诊断妊娠期高血压疾病早期肾损伤价值  

Value of combined detection of urinary β2-MG,KIM-1,and Ang-1 for dignosing of early renal injury in women with hypertensive disorder complicating pregnancy

作　　者：张晓茗 折瑞莲 韩志萍 覃慧君 ZHANG Xiaoming;ZHI Ruilian;HAN Zhiping;QIN Huijun(Shenzhen People's Hospital, Guangdong Province, 518000)

机构地区：[1]深圳市人民医院,518000

出　　处：《中国计划生育学杂志》2021年第2期296-299,303,424,共6页Chinese Journal of Family Planning

摘　　要：目的:研究尿β2-微球蛋白(β2-MG)、肾损伤分子1(KIM-1)、血管紧张素1(Ang-1)检测对妊娠期高血压疾病(HDCP)早期肾损伤价值。方法:选取2016年3月—2019年3月本院收治的HDCP患者100例(妊娠期高血压组31例,子痫前期69例),肾损伤组64例(肾功能损伤)和非肾损伤组36例(肾功能正常),另选同期产前检查健康孕妇50例为对照组。比较各组尿β2-MG、KIM-1、Ang-1水平及与肾功能指标的相关性,以及对HDCP患者早期肾损伤的预测效能。结果:尿素氮、尿酸、尿蛋白、尿蛋白/肌酐值,子痫前期组最高,妊娠期高血压组居中、对照组最低,GFR水平对照组最高、妊娠期高血压组次之、子痫前期组最低;尿β2-MG、KIM-1及Ang-1水平,子痫前期组最高、妊娠期高血压组次之、对照组最低(P<0.05)。尿β2-MG、KIM-1、Ang-1水平,肾损伤组最高、非肾损伤组次之、对照组最低(P<0.05)。尿β2-MG、KIM-1、Ang-1分别与尿素氮、尿酸、24h尿蛋白、尿蛋白/肌酐呈正相关(P<0.05),联合检测的ROC曲线下面积(0.881)最大。结论:β2-MG、KIM-1、Ang-1是HDCP早期肾损伤的敏感指标,联合检测诊断准确性最高。Objective:To investigatethe value of combined detection of urinaryβ2-microglobulin(β2-MG),renal injury molecule 1(KIM-1),and angiotensin 1(Ang-1)for diagnosing early renal injury of pregnant women with hypertensive disorder complicating pregnancy(HDCP).Methods:100 pregant women with HDCP were selected and were divided in group A1(31 women with gestational hypertension)and group A2(69 women with preeclampsia)and divided in group B1(64 women with renal injury)and group B2(36 women without renal injury)from March 2016 to March 2019.50 healthy women were selected in control group during the same period.The levels of urinaryβ2-MG,KIM-1,Ang-1 of women were compared among these groups.The correlations between the levels of urinaryβ2-MG,KIM-1,Ang-1 of women and their renal function indicators were also analyzed.Results:The levels of urea nitrogen,uric acid,and urinary protein,and urinary protein/creatinine value of the women in group A2 were the highest,followed by those of the women in group A1,and those of the women in control group were the lowest.The GFR level of the women in control group was the highest,followed by that of the women in group A1,and that of the women in group A2 was the lowest.The levels of urinaryβ2-MG,KIM-1 and Ang-1 of the women in group A2 were the highest,followed by the women in group A1,and those of the women in control group were the lowest(P<0.05).The levels of urinaryβ2-Mg,KIM-1 and Ang-1 of the women in group B1 were the highest,followed by those of the women in group B2,and those of the women in control group were the lowest(P<0.05).The level of urinaryβ2-Mg,KIM-1,or Ang-1 were positively correlated with urea nitrogen level,uric acid level,24h urinary protein value,or urinary protein/creatinine value(P<0.05).The area under the ROC curve of the combined detection ofβ2-MG,KIM-1 and Ang-1 for diagnosing early renal injury of pregnant women with HDCP was 0.881.Conclusion:β2-MG,KIM-1 and Ang-1 are the sensitive indicators for diagnosing early renal injury of pregnant women with HDCP,

关 键 词：妊娠期高血压疾病 早期肾损伤 尿β2-微球蛋白、肾损伤分子1、血管紧张素1 诊断效能 

分 类 号：R714.246[医药卫生—妇产科学]