妊娠期糖尿病患者血清晚期氧化蛋白产物、活性氧与胰岛素抵抗关系  

Correlation of the levels of serum oxidized protein products and reactive oxygen species of pregnant women with gestational diabetes mellitus and their insulin resistance

作　　者：杨雅嵋 王文平[1] 瞿大成[1] YANG Yamei;WANG Wenping;QU Dacheng(Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan Province, 637000)

机构地区：[1]川北医学院附属医院,南充637000

出　　处：《中国计划生育学杂志》2021年第2期332-335,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨妊娠期糖尿病(GDM)患者血清晚期氧化蛋白产物(AOPP)、活性氧(ROS)与胰岛素抵抗(IR)的相关性。方法:选取2017年6月—2019年7月本院收治的GDM患者150例(GDM组),同期健康体检孕妇100例为对照组。比较两组血清AOPP、ROS水平并行单因素分析、Pearson相关性分析和多元线性回归分析。结果:GDM组体质指数、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、丙氨酸氨基转移酶(ALT)、空腹血糖(FPG)、餐后2h血糖(2hPG)、糖化血红蛋白(HbAlc)、空腹胰岛素(FINS)及胰岛素抵抗指数(HOMA-IR)均高于对照组(P<0.05),两组年龄、孕周、高密度脂蛋白胆固醇(HDL-C)、天冬氨酸氨基转移酶(AST)无差异(P>0.05)。GDM组血清AOPP、ROS水平均高于对照组(P<0.05)。AOPP、ROS与GDM患者IR指标(FINS、HOMA-IR)均呈正相关(P<0.05),BMI、TG、ALT、AOPP、ROS是GDM患者IR的危险因素。结论:GDM患者血清AOPP、ROS水平异常升高,且与IR有密切关系。Objective:To explore the correlation between the levels of advanced oxidation protein product(AOPP)and reactive oxygen species(ROS)in serum of pregnant women with gestational diabetes mellitus(GDM)and their insulin resistance(IR).Methods:From June 2017 to July 2019,150 pregnant women with GDM were selected in study group,and another 100 normal pregnant women were selected in control group during the same period.The serum AOPP and ROS levels of the women were compared between the two groups.Univariate analysis,Pearson correlation analysis and multiple linear regression analysis were performed.Results:The value of body mass index(BMI),and the levels of triglyceride(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),alanine aminotransferase(ALT),fasting plasma glucose(FPG),2 h postprandial blood glucose(2 HPG),glycosylated hemoglobin(HbAlc),and fasting insulin(FINS),and the value of insulin resistance index(HOMA IR)of the women in the study group were significant higher than those of the women in the control group(P<0.05).There were no significant differences in age,gestational weeks,and the levels of high density lipoprotein cholesterol(HDL-C),aspartate aminotransferase(AST)of the women between the two groups(P>0.05).The serum AOPP and ROS levels of the women in the study group were significant higher than those of the women in the control group(P<0.05).In the study group,the levels of AOPP and ROS of the women were positively correlated with their IR indexes(FINS,HOMA-IR)(P<0.05),and BMI value,and the levels of TG,ALT,AOPP and ROS were the risk factors of IR.Conclusion:The AOPP and ROS levels of pregnant women with GDM are abnormally elevated,which have closely relevant to the IR of these women.

关 键 词：妊娠期糖尿病 晚期氧化蛋白产物 活性氧 胰岛素抵抗 

分 类 号：R71[医药卫生—妇产科学]