SLC6A4基因多态性位点rs2020936与中国西北部人群原发性失眠关系的研究  

Study on the Relationship Between rs2020936 of SLC6A4 Gene Polymorphism and Primary Insomnia in Northwestern China

作　　者：陈文娟 谢宇平[2] 周丽雅[2] 王旭斌 王静[3] 马薇[2] 惠培林[2] 王金凤[2] 苏晓艳[2] 郭斌[2] 陈雪萍 范杰 赵媛 杨军[1] 张尚丽 刘瑜 CHEN Wenjuan;XIE Yuping;ZHOU Liya;WANG Xubin;WANG Jing;MA Wei;HUI Peilin;WANG Jinfeng;SU Xiaoyan;GUO Bin;CHEN Xueping;FAN Jie;ZHAO Yuan;YANG Jun;ZHANG Shangli;LIU Yu(Gansu University of Traditional Chinese Medicine,Lanzhou,730000,China;Sleep Medicine Center,Gansu Provincial People's Hospital,Lanzhou 730000,China;Institute of Medical Genetics,School of Basic Medicine,Lanzhou University,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学,兰州730000 [2]甘肃省人民医院睡眠医学中心,兰州730000 [3]兰州大学基础医学学院医学遗传研究所,兰州730000

出　　处：《世界睡眠医学杂志》2021年第2期364-366,共3页World Journal of Sleep Medicine

基　　金：国家自然科学基金项目(81560228);甘肃省卫生行业科研计划项目(GSWSKY-2019-88);甘肃省人民医院院内科研基金项目(18GSSY4-19)。

摘　　要：目的:首次探讨SLC6A4基因多态性位点rs2020936与西北部人群原发性失眠之间的相关性。方法:选取2016年1月至2019年12月甘肃省人民医院睡眠医学中心收治的原发性失眠患者78例作为观察组,另选取同期的体检中心的健康人群82例作为对照组,对受试者进行多导睡眠监测及量表评估,采用飞行质谱法对SNP位点进行基因分型,SPSS 22.0统计软件进行分析。结果:观察组位点rs2020936基因型频率分布符合哈迪-温伯格平衡,与对照组比较,差异有统计学意义(P<0.05),基因型频率、等位基因频率在与对照组比较,差异无统计学意义(P>0.05),对性别进行分层比较亦未见显著性差异。但不同的基因型在REM期(%)(P=0.006%)及患者的睡眠效率(%)(P=0.001)间具有显著性差异。logistic回归分析结果显示,SNP位点rs2020936不是中国西北部人群原发性失眠的危险因素(P=0.735)。结论:SLC6A4基因多态性位点rs2020936可能不是中国西北部人群原发性失眠症的易感位点。Objective:To investigate the correlation between rs2020936 of SLC6A4 gene polymorphism and primary insomnia in northwestern population for the first time.Methods:Between January 2016 and December 2019,gansu province people's hospital treated 78 cases of patients with primary insomnia sleep medical center as observation group,the other selection during the same period of 82 cases of healthy people as control group,the subjects polysomnography and the evaluation of the scale,use of flight mass spectrometry to genotyping SNPS loci SPSS 22.0 statistical software for analysis.Results:The genotype frequency distribution of rs2020936 in the observation group was in line with Hardi-Weinberg balance,and the difference was statistically significant(P<0.05)compared with the control group.There was no statistical difference in the genotype frequency and allele frequency between the observation group and the control group(P>0.05),and there was no significant difference in the stratification of sex.However,there were significant differences in REM stage(%)(P=0.006%)and sleep efficiency(%)(P=0.001)among different genotypes.Logistic regression analysis showed that SNP rs2020936 was not a risk factor for primary insomnia in northwest Chinese population(P=0.735).Conclusion:SLC6A4 gene polymorphism locus rs2020936 may not be the susceptible locus of primary insomnia in northwestern China.

关 键 词：原发性失眠 SLC6A4基因 单核苷酸多态性 

分 类 号：R338.63[医药卫生—人体生理学]