3-氯-2-(二氟甲氧基)-5-(4,4,5,5-四甲基-1,3,2-二氧戊环-2-基)吡啶的合成研究  

Synthesis of 3-chloro-2-(difluoromethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxolanecyclo-2-yl)pyridine

作　　者：肖佳美 蒙应粉 王一醇 王丝丝 李墨晨轩 黄朋越 赵春深[1,2] Xiao Jiamei;Meng Yingfen;Wang Yichun;Wang Sisi;Li Mochenxuan;Huang Pengyue;Zhao Chunshen(School of Pharmaceutical Sciences,Guizhou University,Guiyang 550025;Guizhou Engineering Laboratory for Synthetic Drugs,Guiyang 550025,China)

机构地区：[1]贵州大学药学院,贵州贵阳550025 [2]贵州省合成药物工程实验室,贵州贵阳550025

出　　处：《广东化工》2021年第4期17-17,28,共2页Guangdong Chemical Industry

基　　金：贵州大学大学生“SRT计划”项目:贵大SRT字[2019]436号。

摘　　要：3-氯-2-(二氟甲氧基)-5-(4,4,5,5-四甲基-1,3,2-二氧戊环-2-基)吡啶是一种重要医药化工中间体。本文以2-羟基-5-溴吡啶为原料,对目标化合物的合成进行了研究,此合成方法原料价廉易得、操作简单,总收率为53.15%,适合工业化生产。3-Chloro-2-(difluoromethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxolanecyclo-2-yl)pyridine is an important pharmaceutical and chemical intermediate.In this paper,2-hydroxy-5-bromopyridine was used as the raw material to synthesize the target compound.The synthetic method was cheap and easy to obtain.The yield was 53.15%.It was suitable for industrial production.

关 键 词：3-氯-2-(二氟甲氧基)-5-(4 4 5 5-四甲基-1 3 2-二氧戊环-2-基)吡啶 2-羟基-5-溴吡啶 合成 

分 类 号：TQ[化学工程]