轴手性BINOL双酰胺催化四氢吡喃酮与芳香醛的反应  

A Chiral BINOL Bisamide Catalyzes the Reaction of Tetrahydropyrone with Aromatic Aldehyde

作　　者：刘莉 张敏 陈治明 Liu Li;Zhang Min;Chen Zhiming(School of Chemistry and Materials Science Guizhou Normal University Key Laboratory of Functional Materials Chemistry of Guizhou Province,Guiyang 550001,China)

机构地区：[1]贵州师范大学化学与材料科学学院,贵州省功能材料化学重点实验室,贵州贵阳550001

出　　处：《广东化工》2021年第5期11-12,共2页Guangdong Chemical Industry

基　　金：国家自然科学基金资助项目(21362006)。

摘　　要：3-羟基-2-萘甲酸为原料合成了4种轴手性BINOL双酰胺催化剂2a-2d,应用于四氢吡喃酮与芳香醛反应中。结果表明:在0℃、以CH2Cl2为溶剂,以15 mol%2b为催化剂的体系下反应28 h,得到较高产率(88%)和较好的对映选择性(92%)。Four kinds of axial chiral BINOL bisamide catalysts 2 a-2 d were synthesized from 3-hydroxy-2-naphthoic acid as raw materials, which were used in the reaction of tetrahydropyrone with aromatic aldehyde. The results showed that the reaction was carried out at 0 ℃ in a solvent of CH2 Cl2 with 15 mol% 2 b as a catalyst for 28 h, can be obtained with higher yield(88 %) and better enantioselectivity(92 %).

关 键 词：BINOL酸 四氢吡喃酮 芳香醛 

分 类 号：O626[理学—有机化学]