降钙素受体rs1801197基因多态性与骨质疏松症相关性的Meta分析  

Association of calcitonin receptor rs1801197 polymorphism with osteoporosis:a meta-analysis

作　　者：徐梦圆 李姿萱 宋渐石 王冰霜 赵丽娟[4] Xu Mengyuan;Li Zixuan;Song Jianshi;Wang Bingshuang;Zhao Lijuan(Department of Public Health,Hebei Medical University,Shijiazhuang 050017,China;Department of basic medicine,Hebei Medical University,Shijiazhuang 050017,China;Graduate school,Hebei Medical University,Shijiazhuang 050017,China;Department of Toxicology,Hebei Province Key Laboratory of Environment and Human Health,Hebei Medical University,Shijiazhuang 050017,China)

机构地区：[1]河北医科大学公共卫生学院,石家庄050017 [2]河北医科大学基础医学院,石家庄050017 [3]河北医科大学研究生学院,石家庄050017 [4]河北医科大学卫生毒理学教研室,河北省环境与人群健康重点实验室,石家庄050017

出　　处：《中华老年骨科与康复电子杂志》2021年第2期122-128,共7页Chinese Journal of Geriatric Orthopaedics and Rehabilitation(Electronic Edition)

基　　金：河北医科大学大学生创新性实验计划项目(USIP2019071)。

摘　　要：目的系统评价降钙素受体基因多态性与骨质疏松症的关系。方法计算机检索知网、万方、CBM、PubMed和Embase数据库,搜集CTR基因多态性与骨质疏松症相关性的文献,检索时限从建库至2020年10月。由两名研究者分别独立按照纳入与排除标准筛选文献并提取数据,采用Stata11.0软件进行统计学分析,计算OR值和95%CI。对纳入研究按种族进行亚组分析,最后进行敏感性分析和发表偏倚评估。结果共纳入14项病例-对照研究,共计4059例,并对等位、显性、超显性、共显性基因模型进行Meta分析。结果显示,在等位基因模型(T vs.C:OR=1.564,95%CI:1.013,2.417,P=0.044)、显性基因模型(TT+CT vs.CC:OR=2.436,95%CI:1.351,4.389,P=0.003)和共显性基因模型(CT vs.CC:OR=2.299,95%CI:1.450,3.644,P=0.000)中,高加索人CTR rs1801197基因多态性与骨质疏松症发病风险有显著的相关性。四种基因模型中,亚洲人CTR rs1801197基因多态性与骨质疏松症不存在统计学上的相关性(P>0.05)。研究间未发现有明显发表偏倚。结论Meta分析结果显示,高加索人CTR rs1801197的等位基因模型(T vs.C)、显性模型(TT+CT vs.CC)和共显性模型(CT vs.TT)可能与骨质疏松症患病风险相关。Objective To systematically evaluate the relationship between calcitonin receptor gene polymorphism and osteoporosis.Methods The databases of CNKI,WanFang,CBM,PubMed and Embase were searched by computer to collect the literatures on the correlation between CTR gene polymorphism and osteoporosis,and the retrieval time was from October 2020.Two researchers independently screened the literature according to the inclusion and exclusion criteria and extracted the data.Stata11.0 software was used for statistical analysis,and the OR value and 95%CI were calculated.Subgroup analysis by ethnicity was performed for each included study,followed by sensitivity analysis and publication bias assessment.Results A total of 14 case-control studies(4059 cases in total)were included and meta-analysis was performed on allelic,dominant,superdominant and heterozygous models.The results showed that both the allele model(T vs.C:OR=1.564,95%CI:1.013,2.417,P=0.044)and the dominant gene model(TT+CT vs.CC:OR=2.436,95%CI:1.351,4.389,P=0.003)and heterozygote gene model(CT vs.CC:OR=2.299,95%CI:1.450,3.644,P=0.000),the polymorphism ofCTRrs1801197 gene was significantly correlated with the risk of osteoporosis in Caucasian patients.Among the four gene models,there was no statistical correlation between the polymorphism of CTR rs1801197 gene and osteoporosis inAsians(P>0.05).Nosignificant interstudy publication bias was found.Conclusion Results showed that allele model(T vs.C),dominant model(TT+CT vs.CC)and heterozygote model(CTvs.TT)ofCTRrs1801197wereassociatedwiththe risk of osteoporosis in Caucasians.

关 键 词：降钙素受体 基因多态性 骨质疏松症 META分析 

分 类 号：R580[医药卫生—内分泌]