湿热体质与儿童支原体肺炎临床表现及Th1/Th2免疫应答相关性分析  

Correlation Analysis of Damp-Heat Constitution with Clinical Manifestations and Th1/Th2 Immune Response of Mycoplasma Pneumonia in Children

作　　者：张洪玉 董晓蕾 张海军[2] 房有福[2] 蔺萃[2] ZHANG Hongyu;DONG Xiaolei;ZHANG Haijun;FANG Youfu;LIN Cui(Chinese Medicine Hospital in Qingzhou City,Qingzhou 262500,China;Yidu Central Hospital of Weifang,Qingzhou 262500,China)

机构地区：[1]青州市中医院,山东青州262500 [2]潍坊市益都中心医院,山东青州262500

出　　处：《中国中医药信息杂志》2021年第5期100-103,共4页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：山东省中医药科技发展计划(2017-408)。

摘　　要：目的分析儿童湿热体质支原体肺炎(MPP)的临床表现及Th1/Th2免疫应答特点,为儿童MPP的中医诊治提供参考。方法选择2017年7月-2019年8月MPP住院患儿315例为病例组,同期门诊查体正常儿童300例为正常组,比较2组中医体质分布。将病例组分为湿热质组及非湿热质组,比较2组基本情况、临床表现及Th1/Th2免疫应答特点。结果病例组以湿热体质、阴虚体质多见,分别占37.5%(118/315)、19.0%(60/315),明显高于正常组(P<0.05)。与非湿热质组比较,湿热质组发热、湿啰音比例增加,发热及湿啰音消退时间延长,C反应蛋白(CRP)、乳酸脱氢酶(LDH)、白细胞介素-4、γ干扰素水平明显升高(P<0.05)。结论湿热体质对儿童MPP的发生、发展及转归有较大影响,临床常表现为发热、持续发热、湿啰音及长期湿啰音,CRP、LDH水平升高,可能与湿热体质Th1/Th2免疫应答特点有关。Objective To analyze the clinical manifestations and characteristics of Th1/Th2 immune response in children mycoplasma pneumonia(MPP)with damp-heat constitution;To provide basis for TCM diagnosis and treatment of MPP in children.Methods Totally 315 children with MPP hospitalized between July 2017 and August 2019 were selected as study group.Normal children in outpatient physical examination at the same time were selected as normal group.The proportion of different constitution of TCM between the two groups were compared.The study group was divided into two groups according to different constitutions of TCM:damp-heat constitution group and non damp-heat constitution group.The main clinical manifestations and Th1/Th2 immune response indexes between the two groups were compared.Results Damp-heat constitution and yin-deficiency constitution accounted for 37.5%(118/315)and 19.0%(60/315)respectively in the study group,which was significantly higher than that in the normal group(P<0.05).Compared with the non damp-heat constitution group,the proportion of fever and wet rale in the damp-heat constitution group increased,the time of fever and wet rale subsided was prolonged correspondingly,the levels of CRP,LDH,IL-4 and IFN-γin the damp-heat constitution group were significantly higher(P<0.05).Conclusion Damp-heat constitution is of great significance to the occurrence,development and outcome of children MPP.The clinical manifestations are fever,persistent fever,wet rale and long-term wet rale,and the levels of CRP and LDH increased.This may be related to the characteristics of Th1/Th2 immune response caused by damp-heat constitution.

关 键 词：湿热体质 支原体肺炎 临床表现 TH1/TH2免疫应答 儿童 

分 类 号：R272.956.31[医药卫生—中医儿科学]