表皮细胞种植技术治疗深Ⅱ°烧伤创面临床疗效研究  

Clinical effect of epidermal cell implantation in treatment of deep secondary-degree burn wounds

作　　者：石雪芹 胡大海 王耘川 谢松涛 韩军涛 何亭 张万福 刘梦栋 赵海洋 SHI Xueqin;HU Dahai;WANG Yunchuan;XIE Songtao;HAN Juntao;HE Ting;ZHANG Wanfu;LIU Mengdong;ZHAO Haiyang(Department of Burns and Cutaneous Surgery,Xijing Hospital,Air Force Medical University,Xi’an 710032,China)

机构地区：[1]空军军医大学西京医院烧伤与皮肤外科,陕西西安710032

出　　处：《陕西医学杂志》2021年第5期594-597,共4页Shaanxi Medical Journal

基　　金：国家自然科学基金青年科学基金资助项目(81701902);国家卫生健康委员会公益性行业科研专项项目(201502015)。

摘　　要：目的:探讨表皮细胞种植技术治疗深Ⅱ°烧伤创面的临床疗效。方法:选取符合入组标准的深Ⅱ°烧伤患者70例,随机分为治疗组36例和对照组34例;对照组使用异种脱细胞基质覆盖创面治疗,治疗组采用表皮细胞种植技术治疗;比较两组患者创面细菌含量,创面疼痛NRS评分,瘢痕增生发生情况及创面愈合率。结果:(1)治疗组细菌含量呈逐渐递增、平稳、下降趋势;而同一时间段内,对照组持续上升,两组比较差异均有统计学意义(均P<0.05);(2)治疗组疼痛从中度疼痛递减至轻度疼痛,而对照组持续中度疼痛;两组第6、9、12天NRS评分比较差异均有统计学意义(均P<0.05);(3)治疗组创面愈合率显著高于对照组,两组比较差异有统计学意义(P<0.05);(4)治疗组温哥华瘢痕量表评分,显著低于对照组,两组比较差异均有统计学意义(均P<0.05)。结论:使用表皮细胞种植技术治疗深Ⅱ°烧伤创面,可显著降低创面细菌含量、缓解疼痛、提高治疗效果、减少瘢痕增生的发生、且安全性较好。Objective:To explore the clinical effect of epidermal cell implantation in the treatment of deep secondary-degree burn wounds.Methods:A total of 70 patients with second-degree burns were randomly divided into treatment group(n=36)and control group(n=34).The control group was treated with xenogeneic acellular matrix to cover the wound,and the treatment group was treated with epidermal cell implantation.The bacterial content of the wound,the NRS score of wound pain,the occurrence of scar hyperplasia and the wound healing rate were compared between the two groups.Results:The bacterial content in the treatment group increased first,then stabilized and finally decreased,and that in the control group during the same time period continued to rise,and the difference between the two groups was statistically significant(P<0.05).The pain in the treatment group decreased from moderate pain to mild pain,while the control group continued to have moderate pain,and the differences in NRS scores of the two groups on the 6th,9th and 12th day were statistically significant(all P<0.05).The wound healing rate of the treatment group was significantly higher than that of the control group(P<0.05).Vancouver Scar Scale score of the treatment group was significantly lower than that of the control group(all P<0.05).Conclusion:The application of epidermal cell implantation in the treatment of deep secondary-degree wounds can significantly reduce the bacterial content,relieve pain,improve the treatment effect,reduce the occurrence of scar hyperplasia,and is safe.

关 键 词：烧伤 创面 治疗 表皮细胞种植 异种脱细胞基质 对比研究 

分 类 号：R644[医药卫生—外科学]