靶向共价闭合环状DNA抗HBV治疗的研究进展  

Research advances in anti-hepatitis B virus therapy targeting covalently closed circular DNA

作　　者：王艺颖 刘熙称 朴荣利[1] 秦俊杰[1] WANG Yiying;LIU Xichen;PIAO Rongli;QIN Junjie(Department of Hepatology, The First Hospital of Jilin University, Changchun 130000, China)

机构地区：[1]吉林大学第一医院肝病科,长春130000

出　　处：《临床肝胆病杂志》2021年第5期1189-1192,共4页Journal of Clinical Hepatology

摘　　要：HBV引起尚未治愈的慢性感染,是世界范围内的主要健康负担。共价闭合环状DNA作为稳定的微染色体存在于受感染细胞的细胞核中,当新型治疗手段实现灭活或消除感染肝细胞中持久存在的共价闭合环状DNA,慢性感染自然过程和长期抗病毒治疗将不复存在。介绍了通过基因编辑、表观遗传修饰等方法靶向共价闭合环状DNA,以期完全性治愈HBV感染。The incurable chronic infection caused by hepatitis B virus(HBV)is the major health burden worldwide.Covalently closed circular DNA(cccDNA)exists in the nucleus of infected cells as a stable minichromosome,and when a new therapy realizes inactivation or eliminates persistent cccDNA in infected hepatocytes,the natural process of chronic infection and long-term antiviral therapy will no longer exist.This article introduces the methods targeting cccDNA,such as gene editing and epigenetic modification,so as to achieve the complete cure of HBV infection.

关 键 词：共价闭合环状DNA 乙型肝炎病毒 基因编辑 

分 类 号：R512.62[医药卫生—内科学]