扩散峰度成像技术检测急性期癫痫大鼠模型的成像改变  

A Study on Diffusion Kurtosis Imaging in Acute Epilepsy Rats

作　　者：龚霞蓉[1] 边立功 陈渝晖[1] 陈婧[1] 王波[1] 毕国力[1] GONG Xia-rong;BIAN Li-gong;CHEN Yu-hui;CHEN Jing;WANG Bo;BI Guo-li(MRI Department,The 1st People’s Hospital of Yunnan Province,Kunming Yunnan 650032;Dept.of Anatomy,Histology and Embryology,School of Basic Medicine,Kunming Medical University,Kunming Yunnan 650500,China)

机构地区：[1]云南省第一人民医院磁共振科,云南昆明650032 [2]昆明医科大学基础医学院人体解剖与组织胚胎学系,云南昆明650500

出　　处：《昆明医科大学学报》2021年第4期28-32,共5页Journal of Kunming Medical University

基　　金：云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目[2017FE467(-123),2018FE001(-017)];云南省教育厅科学研究基金资助项目[2014C009];云南省高层次卫生计生人才培养基金资助项目(H-2019070)。

摘　　要：目的探讨扩散峰度成像(diffusion kurtosis imaging,DKI)技术对急性期癫痫大鼠的研究价值。方法Li-Pilocarpine诱导急性期大鼠癫痫模型13只,作为模型组,选取9只正常大鼠作为对照组。采用DKI技术对2组研究对象进行扫描,测量双侧海马、双侧梨状皮层/内嗅皮层的部分各向异性(fractional anisotropy,FA)、平均扩散系数(mean diffusivity,MD)、平均峰度(mean kurtosis,MK)、平行峰度(axial kurtosis,K∥)、径向峰度(radial kurtosis,K⊥)。采用SPSS 17.0统计学软件进行统计学分析。结果与对照组相比,模型组大鼠双侧梨状皮层/内嗅皮层的MD降低,MK、K∥、K⊥升高,差异具有统计学意义(P<0.05)。模型组大鼠双侧海马FA、MD、MK、K∥、K⊥的改变,差异无统计学意义(P>0.05)。结论DKI技术可以反映急性癫痫大鼠的微观病理改变,为急性期癫痫大鼠脑组织的病理生理改变提供理论依据。Objective To investigate brain abnormalities in rats with acute epilepsy by diffusional kurtosis imaging(DKI).Methods MRI were performed on all rats.DKI images were obtained from 13 epilepsy rats and 9 normal controls.Fractional anisotropy(FA),mean diffusivity(MD),and mean kurtosis(MK),axial kurtosis(K∥),radial kurtosis(K⊥)of bilateral hippocampus,piriform cortex and entorhinal cortex were measured.SPSS 17.0 was used for statistical analysis.Results Compared with the control group,MD of bilateral piriform cortex/entorhinal cortex decreased,MK、K∥、K⊥significantly increased in the model group(P<0.05).There were no statistically significant differences in FA,MD,MK,K∥and K⊥in the bilateral hippocampus of model group.Conclusion Using DKI to reveal the pathologic changes of rats with acute epilepsy provide theoretical basis for the pathophysiological changes of brain tissues of rats with acute epilepsy.

关 键 词：癫痫 大鼠 扩散峰度成像 

分 类 号：R445.2[医药卫生—影像医学与核医学]