高龄女性急性心肌梗死患者临床特点及内质网应激因子HSP47、XBP-1S、GRP78的血清含量  

Clinical Characteristics and Serum Levels of Endoplasmic Reticulum Stress Factors HSP47,XBP-1S and GRP78 in Elderly Women with Acute Myocardial Infarction

作　　者：田倪妮 张鸿青[1] 田敏 吕彩萍[1] 杨斌[1] 许峰[1] 李宏键[3] 潘兴华 TIAN Ni-ni;ZHANG Hong-qing;TIAN Min;LV Cai-ping;YANG Bin;XU Feng;LI Hong-jian;PAN Xing-hua(Dept.of Cardiology,Ganmei Hospital Affiliated to Kunming Medical University,Kunming Yunnan 650011;Dept.of Laboratory,Ganmei Hospital Affiliated to Kunming Medical University,Kunming Yunnan 650011;Teaching and Research Office,Kunhua Hospital of Kunming University of Science and Technology;Clinical Laboratory,No.920 Hospital,Joint Support Unit,Kunming Yunnan 650032,China)

机构地区：[1]昆明医科大学附属甘美医院心内科,云南昆明650011 [2]昆明医科大学附属甘美医院检验科,云南昆明650011 [3]昆明理工大学附属昆华医院教研室 [4]联勤保障部队920医院临床实验科,云南昆明650032

出　　处：《昆明医科大学学报》2021年第4期91-95,共5页Journal of Kunming Medical University

基　　金：云南省卫生与计生高层次后备人才工程基金资助项目(H-2018035);昆明市卫生科技人才暨“十百千”工程基金资助项目(2018-SW-55);昆明市卫生和计划生育委员会医药卫生科技计划基金资助项目(2019-03-01-002)。

摘　　要：目的探讨女性心肌梗死患者临床特点及内质网应激蛋白HSP47、XBP-1S、GRP78的血清含量与男性患者的差异。方法急性心肌梗死入院的患者356例,取发病后24 h内静脉血,离心后检测血清HSP47、XBP-1S、GRP78浓度,分为女性组(n=116),男性组(n=240)。临床资料进行独立样本的t检验、卡方检验、非参数秩和检验。结果(1)女性患者组的发病年龄大于男性患者组(P<0.05);(2)女性患者组吸烟率、高血压患病率低于男性患者组(P<0.05);(3)女性患者组血清中XBP-1S含量高于男性患者组(P=0.023,P<0.05);女性患者组血清中HSP47、GRP78含量与男性患者组比较,差异无统计学意义(P>0.05);(4)女性患者组血清GLU水平、BNP水平高于男性患者组(P<0.05),女性患者组HCY(mmol/L)、CREA(mmol/L)、尿酸(mmol/L)、eGFRm水平低于男性组(P<0.05);(5)非ST段抬高型心肌梗死发病率47.4%高于男性组发病率(P<0.05)。结论急性心肌梗死女性患者有较男性患者发病年龄高、血清GLU、BNP含量高,非ST段抬高型心肌梗死发病率女性组高,其发病24 h内具有更高的内质网应激蛋白XBP-1S水平;男性急性心肌梗死患者血清中HCY、CREA、尿酸、eGFRm水平高于女性组。Objective To investigate the clinical characteristics of female patients with myocardial infarction and the differences in serum levels of endoplasmic reticulum stress proteins HSP47,XBP-1S,and GRP78 with male patients.Methods A total of 356 patients with acute myocardial infarction who were admitted to the hospital.The venous blood was collected within 24 hours after the onset,and the serum HSP47,XBP-1S and GRP78 concentrations were measured after centrifugation.They were divided into female group(n=116)and male group(n=240).The independent sample t test,chi-square test and nonparametric rank sum test were used for clinical data analysis.Results The age of onset in the female group was older than that in the male group(P<0.05);while the prevalence of smoking and hypertension in the female group were lower than those in the male group(P<0.05).The level of XBP-1S in serum of female patients was higher than that of male patients(P=0.023,P<0.05);but there was no significant difference in serum HSP47 and GRP78 levels between female patients and male patients(P>0.05).Serum GLU and BNP levels in the female patient group were higher than those in the male patient group(both P<0.05),and the female patient group had lower levels of HCY(mmol/L),CREA(mmol/L),uric acid(mmol/L)and eGFRm than in the male group(all P<0.05).The incidence of non-ST-segment elevation myocardial infarction was 47.4%higher than that of the male group(P<0.05).Conclusion Female patients with acute myocardial infarction have an older age of onset,higher serum GLU and BNP levels.The incidence of non-ST segment elevation myocardial infarction is higher in the female group and higher endoplasmic reticulum stress protein XBP-1S level within 24 hours of onset;while the serum levels of HCY,CREA,uric acid,and eGFRm in male patients with acute myocardial infarction were higher than those in the female group.

关 键 词：急性心肌梗死 女性 内质网应激 剪切型X-盒结合蛋白 

分 类 号：R541.4[医药卫生—心血管疾病]