LncRNA ROR在脂肪源性干细胞中的过表达对面部皮肤老化的影响  

Effect of lncRNA ROR overexpression in adipose-derived stem cells on facial skin aging

作　　者：梁书旗 吴新军[2] 李岩[2] 李建[3] LIANG Shuqi;WU Xinjun;LI Yan;LI Jian(Renzhi college,Sanquan college,Xinxiang Medical College,Xinxiang,Henan,China,453003;The second ward of general surgery,the First Affiliated Hospital of Xinxiang Medical College,Weihui,Henan,China,453100;Department of Cosmetology and Plastic Surgery,the First Affiliated Hospital of Xinxiang Medical College,Weihui,Henan,China,453100)

机构地区：[1]新乡医学院三全学院仁智书院,河南新乡453003 [2]新乡医学院第一附属医院普通外科二病区,河南卫辉453100 [3]新乡医学院第一附属医院美容整形科,河南卫辉453100

出　　处：《分子诊断与治疗杂志》2021年第4期619-622,共4页Journal of Molecular Diagnostics and Therapy

基　　金：河南省医学科技攻关计划项目(2018063251)。

摘　　要：目的探讨长链非编码RNA ROR(LncRNA ROR)在人脂肪源性干细胞中的过表达对面部皮肤老化的影响。方法选取2018年1月至2019年1月本院收治的40例面部老化就医者作为研究组,同时选取同期到本院健康体检者40例作为对照组。采用实时荧光定量聚合酶链反应(qRT-PCR)检测LncRNA ROR在两组研究对象脂肪源性干细胞中的表达水平。比较两组研究对象面部皮肤的斑点、皱纹、皮肤纹理及紫外线色斑情况。采用Pearson法分析LncRNA ROR表达水平与面部指标的相关性。结果与对照组比较,研究组LncRNA ROR的表达水平显著升高(P<0.05)。与对照组比较,研究组斑点、皱纹、皮肤纹理、紫外线色斑评分结果显著升高(P<0.05)。采用Pearson法分析LncRNA ROR表达水平与面部斑点、皱纹、皮肤纹理、紫外线色斑呈正相关(P<0.05),r值分别为0.446、0.527、0.394、0.415。结论 LncRNA ROR在脂肪源性干细胞中的过表达与面部皮肤老化的发生发展呈显著正相关。Objective To investigate the effect of overexpression of lncRNA ROR in adipose-derived stem cells on facial skin aging.Methods Forty patients with facial aging who were treated in our hospital from January 2018 to January 2019 were selected as the study group,and 40 people who underwent health examinations in our hospital during the same period were selected as the control group.Real-time fluorescence quantitative polymerase chain reaction(qRT-PCR)was used to detect the expression level of LncRNA ROR in adipose-derived stem cells in two groups of subjects.The facial skin spots,wrinkles,skin texture,and UV stains of the two groups of subjects were compared.The correlation between LncRNA ROR expression level and facial indicators was analyzed by Pearson analysis.Results Compared with the control group,the expression level of LncRNA ROR in the study group was significantly increased(P<0.05).Compared with the control group,the scores of spots,wrinkles,skin texture,and ultraviolet spots in the study group were significantly increased(P<0.05).The pearson analysis showed that the expression of LncRNA ROR was positively correlated with facial spots,wrinkles,skin texture,and ultraviolet staining(P<0.05).The r values were 0.446,0.527,0.394,and0.415,respectively.Conclusion The overexpression of lncRNA ROR in adipose-derived stem cells is significantly positively correlated with the occurrence and development of facial skin aging.

关 键 词：LncRNA ROR 脂肪源性干细胞 面部皮肤 临床意义 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]