肺结核感染患者中TRF、IAP及HMGB1的表达及意义  

Expression and significance of TRF,IAP and HMGB1 in patients with pulmonary tuberculosis infection

作　　者：王月彩[1] 戎燕筱 王显雷[3] 张敬美[2] 孙扬[4] 苏圆圆[4] WANG Yuecai;RONG Yanxiao;WANG Xianlei;ZHANG Jingmei;SUN Yang;SU Yuanyuan(The Third Department of Tuberculosis,the Fifth Hospital of Shijiazhuang City,Shijiazhuang,Hebei,China,050021;The Second Department of Tuberculosis,the Fifth Hospital of Shijiazhuang City,Shijiazhuang,Hebei,China,050021;The Third Department of Tuberculosis,Hebei Chest Hospital,Shijiazhuang,Hebei,China,050041;The First Department of Tuberculosis,the Fifth Hospital of Shijiazhuang City,Shijiazhuang,Hebei,China,050021)

机构地区：[1]石家庄市第五医院结核三科,河北石家庄050021 [2]石家庄市第五医院结核二科,河北石家庄050021 [3]河北省胸科医院结核三科,河北石家庄050041 [4]石家庄市第五医院结核一科,河北石家庄050021

出　　处：《分子诊断与治疗杂志》2021年第4期643-646,650,共5页Journal of Molecular Diagnostics and Therapy

基　　金：2017年石家庄市科学技术研究与发展计划项目(171461473)。

摘　　要：目的分析肺结核感染患者中血清转铁蛋白(TRF)、免疫抑制酸性蛋白(IAP)及细胞外高迁移率族蛋白B1(HMGB1)的表达及意义。方法选取2017年6月至2019年6月本院收治的142例肺结核患者作为观察组,其中肺结核病灶进展期46例、吸收好转期53例、稳定期43例,选取同期于本院体检的100例健康者作为对照组。对比不同对象TRF、IAP及HMGB1水平,采用Logistic回归分析影响肺结核患者临床转归的相关因素。结果观察组TRF、IAP及HMGB1水平均高于对照组,差异具有统计学意义(P<0.05)。进展期患者TRF、IAP及HMGB1水平均高于吸收好转期及稳定期患者,吸收好转期患者TRF、IAP及HMGB1水平高于稳定期患者,差异均具有统计学意义(P<0.05)。142例肺结核患者治疗无效者41例,有效者101例,治疗有效率为71.13%。机械通气、复发、APACHEⅡ评分、TRF、IAP、HGMB1水平与肺结核患者预后呈正相关(P<0.05),规范化治疗与肺结核患者预后呈负相关(P<0.05)。复发(有)、规范化治疗(否)、APACHE II评分(≥25分)、TRF(异常)、IAP(异常)及HMGB1(异常)水平是影响肺结核患者预后的独立危险因素(P<0.05)。结论 TRF、IAP及HMGB1水平在肺结核患者中显著升高,三者与患者预后转归关系密切,可作为病情监测及预后评估的有效指标。Objective To analyze the expression and significance of serum transferrin(TRF),immunosuppressive acidic protein(IAP)and extracellular high mobility group box-1(HMGB1)in patients with pulmonary tuberculosis infection.Method The total of 142 patients with tuberculosis admitted to our hospital from June 2017 to June 2019 were selected as the observation group,including 46 cases with pulmonary tuberculosis whose lesions were in progressive stage,53 cases in absorption and improvement stage,and43 cases in stable stage.During the same period,100 healthy people who were examined in this hospital were selected as the control group.The levels of TRF,IL-6 and HMGB1 in different subjects were compared.Logistic regression was used to analyze the related factors that affect the clinical outcome of patients with pulmonary tuberculosis.Result The levels of TRF,IAP and HMGB1 in the observation group were higher than those in the control group,the difference was statistically significant(P<0.05).The levels of TRF,IAP and HMGB1 in patients with progressive stage were higher than those in the absorption and improvement stage and the stable stage,and the levels of TRF,IAP and HMGB1 in the absorption and improvement stage were higher than those in the stable stage,the difference was statistically significant(P<0.05).41 cases of 142 pulmonary tuberculosis patients were ineffective in treatment,101 cases were effective,and the effective rate of treatment was71.13%.Mechanical ventilation,recurrence,APACHEⅡscore,TRF,IAP,HGMB1 levels were positively correlated with the prognosis of patients with tuberculosis,and standardized treatment was negatively correlated with the prognosis of patients with tuberculosis(P<0.05).Recurrence(yes),standardized treatment(no),APACHE II score(≥25 points),TRF(abnormal),IAP(abnormal)and HMGB1(abnormal)levels are independent risk factors affecting the prognosis of patients with pulmonary tuberculosis(P<0.05).Conclusion The levels of TRF,IAP and HMGB1 are significantly increased in patients with pulmonary t

关 键 词：肺结核 血清转铁蛋白 IAP HMGB1 

分 类 号：R521[医药卫生—内科学]