广藿香作用的研究进展  

Research Progress on Physiological Activity of Patchouli

作　　者：许家其 张海红 XU Jia-qi;ZHANG Hai-hong(Department of Pharmacy,Hebei North University,Zhangjiakou,075000,China)

机构地区：[1]河北北方学院药学系,中国张家口075000

出　　处：《神经药理学报》2020年第3期27-32,共6页Acta Neuropharmacologica

基　　金：河北北方学院基本科研业务费用项目(No.JYT2020007)。

摘　　要：广藿香是我国十大南药之一,主要功效为祛暑化湿、和胃止呕和芳香化浊。广藿香一般的治疗由广藿香挥发油和水提取物形式进行,其主要成分包括黄酮类、萜类、生物碱和一些醇类等化学物质,其中主要有效成分有广藿香醇、广藿香酮和广藿香烯等,具有抗炎镇痛、保护胃肠道、抗肿瘤、抗疟原虫和抗氧化等作用。广藿香是通过对血清中的前列腺素、丙二醛和一氧化氮的含量进行控制,使血清中这三种物质的含量降低从而发挥抗炎的作用;对胃肠道的保护,广藿香油具有调节胃肠的运动、促进消化液分泌、保护肠屏障的功能;广藿香的水提物和挥发油对于大肠杆菌、金黄色葡萄球菌和白色念珠菌均有一定的抑制作用,其中对金黄色葡萄球菌的抑制作用明显强于肠道杆菌。该文对广藿香及其有效成分的作用进行综述,对今后的研发提供理论基础,促进其在临床医学、化工、中医药领域的应用与开发。Patchouli is one of the top ten southern medicines in China.Its main functions are to dispel heat and dehumidify,prevent stomach vomiting,and aromatize turbidity.Patchouli general forms of treatment by patchouli essential oil and water extract,its main ingredients include flavonoids,terpenoids,alkaloids,and some chemicals,such as alcohols,the major effective components have a wide grandiflorum,sweet alcohol,ketone of patchouli and patchouli ene,etc.,have anti-inflammatory analgesic,protect the gastrointestinal tract,antitumor,anti malaria parasites and antioxidant,etc.Patchouli plays an anti-inflammatory role by controlling the content of prostaglandin,malondialdehyde and nitric oxide in serum.To protect the gastrointestinal tract,patchouli oil plays a role in regulating gastrointestinal movement,promoting digestive secretion,and protecting the intestinal barrier.The water extract and volatile oil of patchouli have certain inhibitory effect on Escherichia coli,Staphylococcus aureus and Candida albicans,among which the inhibitory effect on Staphylococcus aureus is obviously stronger than that on enterobacteria.In this paper,the functions of patchouli and its active components are summarized,which will provide theoretical basis for future research and development and promote its application and development in clinical medicine,chemical industry and traditional Chinese medicine.

关 键 词：广藿香 药理作用 广藿香挥发油 广藿香酮 广藿香醇 

分 类 号：R964[医药卫生—药理学]