亚甲蓝联合纳洛酮治疗急性亚硝酸盐中毒的效果分析  

Effect analysis of methylene blue combined with naloxone in the treatment of acute nitrite poisoning

作　　者：葛树科 GE Shuke(Liaoning Center for Disease Control and Prevention,Shenyang,Liaoning,110079,China)

机构地区：[1]辽宁省疾病预防控制中心,辽宁沈阳110079

出　　处：《当代医学》2021年第14期55-57,共3页Contemporary Medicine

摘　　要：目的探究亚甲蓝联合纳洛酮治疗急性亚硝酸盐中毒的效果。方法选取本院2018年7月至2020年3月收治的78例急性亚硝酸盐中毒患者,根据电脑随机法分为对照组和研究组,每组39例。对照组单独使用亚甲蓝治疗,研究组在对照组基础上使用纳洛酮,比较两组总有效率、用药安全性、KPS评分、平均救治时间、意识恢复时间、死亡率等指标。结果治疗后,研究组总有效率(92.31%)明显高于对照组(64.10%),差异有统计学意义(P<0.05);研究组救治时间、意识恢复时间均短于对照组,差异有统计学意义(P<0.05);研究组不良反应发生率低于对照组,但差异无统计学意义;研究组死亡率明显低于对照组,差异有统计学意义(P<0.05);研究组KPS评分高于对照组,差异有统计学意义(P<0.05)。结论采用亚甲蓝联合纳洛酮治疗急性亚硝酸盐中毒患者,疗效显著,且安全性高,可有效改善患者病情进展,促进预后恢复,值得临床推广运用。Objective To explore the effect of methylene blue combined with naloxone in the treatment of acute nitrite poisoning.Methods 78 patients with acute nitrite poisoning in our hospital from July 2018 to March 2020 were selected and they were randomly divided into control group and study group,with 39 cases in each group.The control group was treated with methylene blue alone,and the study group was treated with naloxone on the basis of the control group.The total effective rate,medication safety,KPS score,average treatment time,consciousness recovery time,mortality and other indicators between the two groups were compared.Results After treatment,the total effective rate of the study group(92.31%)was significantly higher than that of the control group(64.10%),the difference was statistically significant(P<0.05);the treatment time and consciousness recovery time of the study group were shorter than those of the control group,the difference was statistically significant(P<0.05);the incidence of adverse reactions of the study group was lower than that of the control group,but the difference was not statistically significant;the mortality of the study group was significantly lower than that of the control group,the difference was statistically significant(P<0.05);the KPS score of the study group was higher than that of the control group,the difference was statistically significant(P<0.05).Conclusion Methylene blue combined with naloxone in patients with acute nitrite poisoning is effective and safe,which can effectively improve the progress of the disease and promote the recovery of prognosis,and is worthy of clinical application.

关 键 词：急性亚硝酸盐中毒 亚甲蓝 纳洛酮 用药安全性 死亡情况 KPS评分 

分 类 号：R595[医药卫生—内科学]