槐杞黄颗粒治疗慢性湿疹的疗效及对干扰素-γ、白细胞介素-4水平的影响  

Efficacy of Huaiqihuang Granule in chronic eczema and its influence on levels of interferon-γand interleukin-4

作　　者：何谐 郝思雨[1] 张宇[1] 党林 HE Xie;HAO Siyu;ZHANG Yu;DANG Lin(Department of Dermatology,the 2nd Affiliated Hospital of Harbin Medical University,Heilongjiang,Harbin 150081,China;Department of Dermatology,Shenzhen People's Hospital,Guangdong,Shenzhen 518020,China)

机构地区：[1]哈尔滨医科大学附属第二医院皮肤科,黑龙江哈尔滨150081 [2]深圳市人民医院皮肤科,广东深圳518020

出　　处：《中国医药科学》2021年第8期1-5,共5页China Medicine And Pharmacy

基　　金：湖北陈孝平科技发展基金会资助项目(CYPJJH11800005-08)。

摘　　要：目的观察槐杞黄颗粒治疗慢性湿疹的临床疗效及对患者血清干扰素-γ(IFN-γ)、白细胞介素-4(IL-4)水平的影响。方法选取2020年1—6月哈尔滨医科大学附属第二医院皮肤科门诊收治的60例慢性湿疹患者,随机分为治疗组和对照组,每组各30例。对照组采用糠酸莫米松乳膏外用治疗,治疗组在对照组的基础上加用槐杞黄颗粒口服,疗程均为4周。治疗后评价两组的临床疗效、安全性,观察治疗后3个月的复发情况,并比较两组治疗前后血清IFN-γ及IL-4水平。结果治疗后,两组湿疹面积及严重度指数(EASI)评分及瘙痒程度评分均较治疗前显著降低(P<0.05),两组间比较差异有统计学意义(P<0.05)。治疗组总有效率(86.67%)与对照组(63.33%)相比,差异有统计学意义(P<0.05)。治疗组复发率(7.69%)低于对照组(36.84%),两组比较差异有统计学意义(P<0.05)。用药期间治疗组和对照组不良反应发生率分别为10.00%和3.33%,两组比较差异无统计学意义(P>0.05)。治疗后,治疗组血清IFN-γ水平显著升高(P<0.05),IL-4水平显著降低(P<0.05),与对照组相比,差异均有统计学意义(P<0.05)。治疗后,对照组血清IL-4水平显著降低(P<0.05),IFN-γ水平无明显变化(P>0.05)。结论槐杞黄颗粒联合糠酸莫米松乳膏治疗慢性湿疹的临床疗效及安全性较好,可有效降低复发率,其作用机制可能与上调IFN-γ、下调IL-4水平有关。Objective To observe the clinical efficacy of Huaiqihuang Granule in chronic eczema and its influence on levels of serum interferon-γ(IFN-γ)and interleukin-4(IL-4).Methods Sixty patients with chronic eczema admitted to the dermatological clinic of the 2nd Affiliated Hospital of Harbin Medical University from January to June 2020 were selected,and they were randomly divided into the treatment group and the control group,with 30 cases in each group.The control group was treated with mometasone furoate cream for external use,while the treatment group was treated with Huaiqihuang Granule orally on the basis of the control group,and the course of treatment was 4 weeks.After treatment,the clinical efficacy and safety of the two groups were evaluated,the recurrence of 3 months after treatment was observed,and the serum IFN-γand IL-4 levels of the two groups before and after treatment were compared.Results After treatment,the score of eczema area and severity index(EASI)and itching degree of the two groups were significantly lower than those before treatment(P<0.05),with statistically significant differences between the two groups(P<0.05).The total effective rate was significantly higher in the treatment group(86.67%)than that in the control group(63.33%),with significant statistical difference between the two groups(P<0.05).The recurrence rate was lower in the treatment group(7.69%)than that in the control group(36.84%),and the difference between the two groups was statistically significant(P<0.05).The incidence of adverse reactions in the treatment group and the control group were 10.00%and 3.33%,respectively,and there was no significant difference between the two groups(P>0.05).After treatment,the level of serum IFN-γin the treatment group was significantly increased(P<0.05),and the IL-4 level was significantly decreased(P<0.05).Compared with the control group,the differences were statistically significant(P<0.05).After treatment,the level of serum IL-4 in the control group decreased significantly(P<0.05),but the

关 键 词：湿疹 槐杞黄颗粒 干扰素-Γ 白细胞介素-4 

分 类 号：R275.9[医药卫生—中西医结合]