移植肾抗体介导的排斥反应的病理学  

Pathology of antibody-mediated rejection in renal allograft

作　　者：郭晖[1] Guo Hui(Organ Transplantation Institute,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Key Laboratory of Organ Transplantation of Ministry of Education,Key Laboratory of Organ Transplantation of National Health Commission of China,Key Laboratory of Organ Transplantation of Chinese Academy of Medical Sciences,Wuhan 430030,China)

机构地区：[1]华中科技大学同济医学院附属同济医院器官移植研究所,器官移植教育部重点实验室,国家卫生健康委员会器官移植重点实验室,中国医学科学院器官移植重点实验室,武汉430030

出　　处：《器官移植》2021年第3期262-271,共10页Organ Transplantation

基　　金：中国医学科学院中央级公益性科研院所基本科研业务费专项资金资助(2019PT320014)。

摘　　要：抗体介导的排斥反应(AMR)亦称体液性排斥反应,是由抗体、补体等多种体液免疫效应因子参与所致的排斥反应免疫损伤。AMR在超急性排斥反应、急性排斥反应以及慢性排斥反应中均发挥了重要的致病作用。本文对AMR的基本定义、Banff移植病理学诊断标准(Banff标准)中AMR病理学的研究历程及其主要成果以及移植肾AMR的主要病变特征进行综述,旨在为准确诊断、及时治疗AMR提供依据,以保障移植肾和受者的长期存活。Antibody-mediated rejection(AMR),also known as humoral rejection,is an immune injury caused by rejection involved with multiple humoral immune effectors,such as antibodies and complements,etc.AMR plays a pivotal role in hyperacute,acute and chronic rejection.In this article,the basic definition of AMR,the research progress and major achievements on AMR pathology according to Banff classification on allograft pathology(Banff classification),and main pathological characteristics of AMR in renal allograft were reviewed,aiming to provide reference for accurate diagnosis and timely treatment of AMR,and guarantee the long-term survival of renal graft and recipients.

关 键 词：抗体介导的排斥反应(AMR) 供者特异性抗体(DSA) 抗体依赖细胞介导的细胞毒作用(ADCC) T细胞介导的排斥反应(TCMR) Banff移植病理学诊断标准(Banff标准) C4D 血栓性微血管病 慢性移植物血管病 

分 类 号：R617[医药卫生—外科学] R36[医药卫生—临床医学]