葫芦巴碱调节肾移植术后代谢紊乱的应用前景  

Application prospects of trigonelline in regulating metabolic disorders after renal transplantation

作　　者：黎忠大 刘东[2] 王晓[2] 庄锦炀 Li Zhongda;Liu Dong;Wang Xiao;Zhuang Jinyang(Guangdong Medical University,Zhanjiang 524023,China)

机构地区：[1]广东医科大学,广东湛江524023 [2]广东省第二人民医院器官移植科

出　　处：《器官移植》2021年第3期363-368,共6页Organ Transplantation

基　　金：广东省医学科研基金(A2020371);广州市科技计划项目(201804010421)。

摘　　要：肾移植术后易发生糖、脂质等代谢紊乱,导致移植肾功能障碍及长期存活率降低。葫芦巴碱是一种具有多种生物活性的天然生物碱,具有改善糖、脂质等代谢紊乱的作用,可减轻肾脏的炎症反应、氧化应激及细胞凋亡,从而保护肾功能。因此,葫芦巴碱可能是调节肾移植术后代谢紊乱的潜在药物。本文对葫芦巴碱与糖代谢紊乱、脂质代谢紊乱、其他代谢紊乱及葫芦巴碱在肾移植中的应用前景进行综述,旨在为改善肾移植术后代谢紊乱、提高肾移植受者及移植肾的长期存活率提供参考。Metabolic disorders,such as glucose and lipid,are likely to occur after renal transplantation,leading to graft dysfunction and reduced long-term survival.Trigonelline is a type of natural alkaloid with various biological activities,which can alleviate the metabolic disorders of glucose,lipid and other types,and relieve inflammatory reaction,oxidative stress and cell apoptosis of the kidney,thereby protecting the renal function.Therefore,trigonelline may be a potential drug to regulate metabolic disorders after renal transplantation.In this article,the role of trigonelline in metabolic disorders of glucose,lipid and other types,and its application prospect in renal transplantation were reviewed,aiming to provide reference for alleviating metabolic disorders after renal transplantation and improving the long-term survival of renal transplant recipients and transplanted kidneys.

关 键 词：葫芦巴碱 肾移植 代谢紊乱 炎症反应 氧化应激 细胞凋亡 免疫抑制剂 糖皮质激素 

分 类 号：R617[医药卫生—外科学] R589[医药卫生—临床医学]