机械牵张促进干细胞衍生心肌样细胞进一步成熟的研究进展  

Recent Advances on Maturation of Stem Cell-Derived Cardiomyocytes Promoted by Myocardial Infarction

作　　者：古兴旺 周帆 穆军升 GU Xingwang;ZHOU Fan;MU Junsheng(Capital Medical University,Beijing 100069,China;Department of Ultrasound,The Third Medical Center of Chinese PLA General Hospital,Beijing 100039,China;Department of Cardiac Surgery,Beijing Anzhen Hospital,Beijing 100029,China)

机构地区：[1]首都医科大学,北京100069 [2]中国人民解放军总医院第三医学中心超声科,北京100039 [3]北京市安贞医院心外科,北京100029

出　　处：《心血管病学进展》2021年第4期351-355,共5页Advances in Cardiovascular Diseases

基　　金：国家自然科学基金(81870181);首都医科大学学生科研创新项目(XSKY2020205)。

摘　　要：心肌梗死发生后,梗死的心肌将逐渐由纤维组织代替,并永久地造成心功能下降。干细胞由于其多向分化潜能,在组织修复重生方面有着巨大的潜能,因此,将干细胞疗法应用于心肌梗死来逆转下降的心功能便是一条可行的思路。既往已有方法可促进干细胞分化为有功能的心肌样细胞,但这种细胞的幼稚表型限制其进一步临床应用,因此,目前的难点主要在于如何提高此种细胞的成熟度以达到临床要求。在多种促成熟方式中,机械牵张被认为具有较大的潜能,在未来可能有广阔的应用前景,但现存的促成熟效率低下和信号转导机制认知不足等问题仍有待解决。After myocardial infarction,the infarcted myocardium will gradually be replaced by fibrous tissue and permanently cause a decline in cardiac function.Stem cells have great potential in the tissue regeneration area due to their multi-directional differentiation potential.Therefore,integrating stem cells into the treatment of myocardial infarction to reverse the decline of cardiac function could be a feasible idea.Previously,different ways have been shown to promote the differentiation of stem cells into functional cardiomyocyte-like cells.However,the naive phenotype of them restrict their further clinical application.Thus,current difficult lies mainly in how to improve the maturity of this kind of cells to meet the clinical requirements.Here,mechanical stretch is considered to have great in this respect and might be put into broad application in the future,but barriers such as insufficiency in promoting maturity and lack of cognition of molecular mechanism remain to be solved.

关 键 词：机械牵张 干细胞衍生心肌细胞 心肌细胞成熟 心肌梗死 

分 类 号：R54[医药卫生—心血管疾病]