去势抵抗性前列腺癌PDX模型研究进展  

Research progress in PDX models of castration-resistant prostate cancer

作　　者：税雪 许荣 赵菊梅[1] 师长宏 SHUI Xue;XU Rong;ZHAO Jumei;SHI Changhong(Medical College of Yanan University,Yan’an 716000,China;Laboratory Animal Center,the Air Force Medical University,Xi’an 710032)

机构地区：[1]延安大学医学院,陕西延安716000 [2]空军军医大学实验动物中心,西安710032

出　　处：《中国实验动物学报》2021年第2期230-235,共6页Acta Laboratorium Animalis Scientia Sinica

基　　金：国家自然科学基金(32070532)。

摘　　要：去势抵抗性前列腺癌(castration-resistant prostate cancer,CRPC)具有较高的发病率和死亡率,是前列腺癌的主要临床特征,且预后较差。建立具有CRPC特征的肿瘤病人临床手术标本异种移植(patient-derived xenograft,PDX)模型对于前列腺癌研究具有重要的意义。本文重点综述了多种CRPC PDX模型的主要表型特征,包括激素非依赖表型、雄激素受体相关表型和神经内分泌表型,以及病理生理学特征,以期为CRPC的发生机制和靶向药物筛选研究提供良好的实验工具。Castration-resistant prostate cancer(CRPC)has high morbidity and mortality,and the prognosis for patients is poor.Establishing patient-derived xenograft models with CRPC characteristics using clinical surgical specimens is critical for CRPC research.In this article,we review the main phenotypic characteristics of a variety of CRPC patientderived xenograft models,including hormone-independent phenotypes,androgen receptor-related phenotypes and neuroendocrine phenotypes,as well as pathophysiological characteristics,and we discuss potential experimental tools for studying the mechanisms of CRPC and for targeted drug screening for the disease.

关 键 词：去势抵抗性前列腺癌 PDX模型 雄激素受体 神经内分泌分化 

分 类 号：Q95-33[生物学—动物学]