肺动脉高压动物模型研究进展  

Research progress in animal models of pulmonary arterial hypertension

作　　者：刘云[1] 孙增先[1] LIU Yun;SUN Zengxian(Department of Pharmacy,the First People’s Hospital of Lianyungang,Lianyungang 222061,China)

机构地区：[1]连云港市第一人民医院药学部,江苏连云港222061

出　　处：《中国实验动物学报》2021年第2期236-241,共6页Acta Laboratorium Animalis Scientia Sinica

基　　金：国家自然科学基金(31871155)。

摘　　要：肺动脉高压(pulmonary arterial hypertension,PAH)是一种预后不良的严重疾病,其发病机制仍不清楚。现有的治疗手段不能治愈,只能减缓疾病的进程。动物模型是研究PAH的重要工具,在PAH病理生理机制研究和防治策略评估中发挥极其重要的作用。本文对经典PAH动物模型(缺氧和野百合碱模型)和PAH双击动物模型的血液动力学改变和肺动脉组织学重构特征进行综述,旨在为PAH新机制和新靶点研究的动物模型选择提供参考。Pulmonary arterial hypertension(PAH)is a serious disease with poor prognosis,and its pathogenesis is still unclear.Current treatment method cannot cure the disease,and can only slow down its progression.Animal models are important tools for the study of PAH,and they play an extremely important role in the study of the pathophysiological mechanisms of the disease and in the evaluation of prevention and treatment strategies.In this review,we discuss the hemodynamic changes and pulmonary artery histological remodeling characteristics of classic PAH animal models(hypoxia and monocrotaline models)and PAH double-clip animal models,with the aim of providing a reference for the selection of animal models for the study of novel mechanisms and new targets for the disease.

关 键 词：肺动脉高压 动物模型 缺氧 野百合碱 

分 类 号：Q95-33[生物学—动物学]