巨噬细胞在系统性红斑狼疮发病机制中的研究进展  

Research progress of macrophages in the pathogenesis of systemic lupus erythematosus

作　　者：唐俊[1] 尤燕舞[2] TANG Jun;YOU Yanwu(Department of Dermatology,Affiliated Hospital of Youjiang Medical University for Nationalities,Baise 533000,Guangxi,China;Department of Nephrology,Affiliated Hospital of Youjiang Medical University for Nationalities,Baise 533000,Guangxi,China)

机构地区：[1]右江民族医学院附属医院皮肤科,广西百色533000 [2]右江民族医学院附属医院肾内科,广西百色533000

出　　处：《右江医学》2021年第4期241-245,共5页Chinese Youjiang Medical Journal

基　　金：国家自然科学基金(81860296)。

摘　　要：系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种慢性系统性免疫性疾病,发病机制较为复杂,可累及多器官系统。巨噬细胞是炎症和宿主防御中的一线天然免疫细胞,它们在整个人体中处于战略地位,其功能是检测、摄取和降解入侵的病原体、免疫复合物、微粒和其他有害物质,从而引起机体对病原体或受损组织产生免疫反应。该综述就巨噬细胞在系统性红斑狼疮发病机制中的作用作一总结。Systemic lupus erythematosus(SLE)is a chronic systemic immune disease with complex pathogenesis that can involve multiple organ systems.Macrophages are frontline natural immune cells in inflammation and host defense.They are in a strategic position throughout the human body.Their function is to detect,ingest and degrade invading pathogens,immune complexes,particles and other harmful substances,thereby causing an immune response to pathogens or damaged tissues.This article summarizes the role of macrophages in the pathogenesis of systemic lupus erythematosus.

关 键 词：巨噬细胞 系统性红斑狼疮 发病机制 

分 类 号：R593.24[医药卫生—内科学]