基因药物肺部递送系统的研究进展  

Research progress of gene drug pulmonary delivery system

作　　者：李月 孙景鑫 金光玉 金勇[1] 孙丹丹[1] 全姬善[1] LI Yue;SUN Jingxin;JIN Guangyu;JIN Yong;SUN Dandan;QUAN Jishan(College of Pharmacy,Yanbian University,Yanji 133000,China;Department of Radiology,Yanbian University Hospital,Yanji 133000,China)

机构地区：[1]延边大学药学院,吉林延吉133000 [2]延边大学附属医院放射科,吉林延吉133000

出　　处：《药学研究》2021年第4期251-254,共4页Journal of Pharmaceutical Research

基　　金：国家自然科学基金(No.81560578、81860304);吉林省科技厅自然科学基金项目(No.20190201251JC)。

摘　　要：哮喘、肺气肿、囊性纤维化、肺部病毒感染和肺癌等多种肺部疾病严重影响人类的健康。基因治疗为肺部疾病治疗开辟了一个新的治疗途径。但因裸露的治疗基因易被降解、靶向能力差,因此需要安全有效的传递系统。本文将对基因药物在体内递送至肺部的给药屏障及可行性方法进行讨论。Various lung diseases such as asthma,emphysema,cystic fibrosis,lung virus infection and lung cancer have severely affected human health.Gene therapy has opened up a new therapeutic approach for the treatment of lung diseases.However,because naked therapeutic genes are easily degraded and have poor targeting ability,a safe and effective delivery system is needed.This article will discuss the drug delivery barriers and feasible methods for gene drug delivery to the lungs in vivo.

关 键 词：基因治疗 非病毒基因载体 肺部给药屏障 肺部给药 

分 类 号：R974[医药卫生—药品]