沙美特罗替卡松粉吸入剂联合无创正压通气治疗慢性阻塞性肺疾病合并呼吸衰竭的效果  

Effect of Salmeterol Ticasone Powder Inhaler combined with noninvasive positive pressure ventilation in the treatment of chronic obstructive pulmonary disease complicated with respiratory failure

作　　者：杜林[1] 张喜畅 DU Lin;ZHANG Xi-chang(Teaching and Research Office of Internal Medicine,Changchun Medical College,Jilin Province,Changchun130000,China;Department of Internal Medicine,People's Hospital in Lvyuan District of Changchun City,Jilin Province,Changchun130000,China)

机构地区：[1]长春医学高等专科学校内科教研室,吉林长春130000 [2]长春市绿园区人民医院内科,吉林长春130000

出　　处：《中国当代医药》2021年第13期67-70,共4页China Modern Medicine

摘　　要：目的探讨沙美特罗替卡松粉吸入剂联合无创通气无创通气(NPPV)治疗慢性阻塞性肺疾病(COPD)合并呼吸衰竭的有效性和安全性。方法选取2018年12月~2019年12月长春市绿园区人民医院诊治的50例COPD合并呼吸衰竭患者作为研究对象,按随机数字表法将其分为研究组与对照组,每组各25例。对照组患者在常规治疗的基础上使用NPPV进行治疗;研究组患者在常规治疗的基础上采用沙美特罗替卡松粉吸入剂联合NPPV治疗。比较分析两组患者治疗后的效果;比较两组患者治疗前后的肺功能情况;比较两组患者的不良反应总发生率。结果研究组患者治疗后的治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者的第1秒用力呼气容积(FEV1)、FEV1占用力肺活量的比值(FEV1%)、用力呼气量占用力肺活量的比值(FEV1/FVC)以及6 min步行试验(6MWT)比较,差异无统计学意义(P>0.05)。治疗后,研究组患者的FEV1、FEV1%以及FEV1/FVC高于对照组,6MWT长于对照组,差异有统计学意义(P<0.05)。治疗后,研究组患者的不良反应总发生率低于对照组,差异有统计学意义(P<0.05)。结论使用沙美特罗替卡松粉吸入剂联合NPPV治疗COPD合并呼吸衰竭,临床效果突出,能明显改善患者肺功能指标,患者经治疗后的临床不良反应总发生率明显降低,该方案安全有效,值得推广。Objective To investigate the efficacy and safety of Salmeterol Ticasone Powder Inhaler combined with noninvasive positive pressure ventilation(NPPV)in the treatment of chronic obstructive pulmonary disease(COPD)complicated with respiratory failure.Methods A total of 50 patients with COPD complicated with respiratory failure who were treated in the People′s Hospital in Lvyuan District of Changchun City from December 2018 to December 2019 were selected as the research subjects,and they were divided into study group and control group according to random number table method,with 25 cases in each group.Control group was treated with NPPV on the basis of conventional treatment.Patients in the study group received Salmeterol Ticasone Powder Inhaler combined with NPPV in addition to conventional treatment.The therapeutic effect of the two groups was compared and analyzed.Lung function before and after treatment was compared between the two groups.The total incidence of adverse reactions was compared between the two groups.Results The total effective rate in the study group was higher than that in the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in the forced expiratory volume in the first second(FEV1),the ratio of FEV1 to forced vital capacity(FEV1%),the ratio of forced expiratory volume to forced vital capacity(FEV1/FVC)and the 6 min walk test(6MWT)between the two groups(P>0.05).After treatment,FEV1,FEV1%and FEV1/FVC in the study group were higher than those in the control group,and 6MWT was longer than that in the control group,with statistically significant differences(P<0.05).After treatment,the total incidence of adverse reactions in the study group was lower than that in the control group,with statistical significance(P<0.05).Conclusion The use of Salmeterol Ticasone Powder Inhaler combined with NPPV in the treatment of COPD complicated with respiratory failure has outstanding clinical effect,which can significantly improve the pulmo

关 键 词：沙美特罗替卡松粉吸入剂 无创正压通气治疗 慢性阻塞性肺疾病 呼吸衰竭 治疗总有效率 肺功能 

分 类 号：R563[医药卫生—呼吸系统]