4例糖尿病肾脏病伴膜性肾病的临床病理及预后分析  

Clinicopathological and Prognostic Analysis of Biopsy-proven Diabetic Kidney Disease with Membranous Nephropathy in Patients with Type 2 Diabetes

作　　者：周越 张帆[1] 罗琼[1] 侯霜[1] ZHOU Yue;ZHANG Fan;LUO Qiong;HOU Shuang(Department of Nephrology,Peking University Shenzhen Hospital,Shenzhen 518036,Guangdong Province,China)

机构地区：[1]北京大学深圳医院肾内科,广东深圳518036

出　　处：《罕少疾病杂志》2021年第3期5-7,共3页Journal of Rare and Uncommon Diseases

基　　金：深圳市三名工程项目资助(SZSM201812097)。

摘　　要：目的探讨2型糖尿病(T2DM)患者糖尿病肾脏病(DKD)伴膜性肾病(MN)的临床与病理特点及预后情况。方法选取T2DM病理为DKD伴MN的患者4例,对其临床病理资料及预后进行分析。结果DKD伴MN患者,本研究4例均表现为肾病综合征(NS);出现血栓并发症的T2DM伴NS者,需警惕伴MN;DKD伴MN者,电镜下可有典型表现;MN经治疗后病情改善。结论DKD伴MN患者,NS表现较多,需重视血栓的防治,积极治疗MN有益于改善肾脏病预后。Objective We aimed to analyze the clinical and pathological features and prognosis of diabetic kidney diseases(DKD)with membranous nephropathy(MN)in patients with type 2 diabetes mellitus(T2DM).Methods We studied 4 patients with DKD and MN,and conducted their clinicopathological data and prognosis.Results In our study,the 4 patients with DKD coincidences with MN all showed nephrotic syndrome(NS).For T2DM with NS complicated with thrombotic complications should be vigilant with MN.DKD with MN may have typical manifestations under the electron microscope.The prognosis of the patients with MN is improved after treatment.Conclusion NS is more common in patients with DKD and MN.So more attention should be paid to the prevention and treatment of thrombosis.Active treatment of MN is beneficial to improve the prognosis of renal disease.

关 键 词：2型糖尿病 糖尿病肾脏病 膜性肾病 肾脏病理 

分 类 号：R587.1[医药卫生—内分泌]