正常成人全脑CT灌注特征的分析  

The Characteristics of CT Cerebral Perfusion Imaging in Normal Adult

作　　者：刘新立[1] 吕新胜[1] 伊力亚斯 汪文涛 赵芳[1] 周宏伟[1] LIU Xin-li;LYU Xin-sheng;ILIYASI;WANG Wen-tao;ZHAO Fang;ZHOU Hong-wei(Department of Medical Imaging,Karamay Central Hospital,Karamay 834000,Xinjiang Uygur Autonomous Region,China)

机构地区：[1]新疆克拉玛依市中心医院医学影像科,新疆克拉玛依834000

出　　处：《罕少疾病杂志》2021年第3期19-23,共5页Journal of Rare and Uncommon Diseases

基　　金：2017年克拉玛依市创新人才工程科技项目(2017RC001A-07)。

摘　　要：目的探讨正常成人全脑CT灌注成像(CTP)的脑血流灌注特征。方法收集58例正常成年人的脑CTP检查数据进行分析。每例选4个层面的灌注图像,小脑最大层面、枕叶最大层面、基底节层面及半卵圆中心层面。分别标注双侧额叶、颞叶、枕叶、顶叶的灰质和白质以及基底节灰质核团的感兴趣区(ROI),测量每个ROI内的灌注参数并进行定量分析,包括脑血容量(CBV)、达峰时间(TTP)、脑血流量(CBF)及平均通过时间(MTT)的数值。结果正常成人小脑灰质的区域平均脑血流量(rCBV)的值最高,左右侧均值分别为(2.728±0.5893)ml/100g、(2.740±0.5374)ml/100g。左右对应脑区的灌注参数的配对t检验的差异无统计学意义(检验水准:双侧α=0.05)。在小脑灰/白质TTP、枕叶灰/白质CBF及额叶灰/白质MTT的配对t检验中,灰质与白质间的差异无统计学意义(P=0.789、0.385、0.205),其余对应灰白质间配对的组各参数值的差异均有统计学意义(检验水准:双侧α=0.05)。对不同脑区灰质与灰质、白质与白质方差分析及多重两两比较后:(1)小脑灰质与额叶、颞叶、枕叶、顶叶灰质间的CBV值的差异有统计学意义(P值分别为0.003、0.001、0.001、0.000);小脑灰质与颞叶、枕叶、顶叶灰质的CBF值的差异有统计学意义(P值分别为0.009、0.050、0.002);枕叶灰质与小脑、颞叶灰质的MTT值的差异有统计学意义(P值分别为0.005、0.013.)。(2)不同脑区灰质之间、白质之间的TTP值的差异均没有统计学意义。(3)不同脑区白质之间的CBV、CBF及MTT值在大多数脑区的差异都有统计学意义。(检验水准:双侧α=0.05)。结论全脑CTP技术可以作为一种活体脑血流动力学测量的可靠的影像学方法。正常成人的大脑半球与小脑之间或同一脑区灰白质之间灌注状态不同。TTP值在不同的脑区或不同灰/白质中一致性最好;CBV及CBF值在大脑的各区域中有较好一致性,但是在小脑Objective To investigate the cerebral blood perfusion characteristics in normal adults by whole-brain CT perfusion imaging(CTP).Methods 58 cases of brain CTP examination data were collected and analyzed,and each case met the criteria of normal adults.Four levels of perfusion images were selected from each case data,including the largest level of the cerebellum,the largest level of the occipital lobe,the basal ganglia level,and the semi-oval center level.The respective regions of interest(ROI)are marked in the gray matter and white matter of the bilateral frontal lobe,temporal lobe,occipital lobe,parietal lobe,and basal ganglia nucleus,then,perfusion parameters within each ROI were measured and quantified,including cerebral blood volume(CBV),time to peak(TTP),cerebral blood flow(CBF),and mean transit time(MTT)values.Results For normal adults,the regional cerebral blood flow(rCBV)value of the cerebellar gray matter was the highest,and the mean values of the left and right sides were(2.728±0.5893)ml/100g and(2.740±0.5374)ml/100g,respectively.There was no statistically significant difference in the Paired-Sample T-Test between the left and right brain regions'perfusion parameters(test criteria:bilateralα=0.05).In the Paired-Sample T-Test of cerebellar gray/white matter TTP,occipital gray/white matter CBF,and frontal ash/white matter MTT,there was no statistically significant difference between gray matter and white matter(P=0.789,0.385,0.205.),and the differences of the parameters of the other groups corresponding to gray matter were statistically significant.According to the ANOVA and Multiple comparison results between gray matter and gray matter,white matter and white matter in different brain regions:(1)There was a statistically significant difference in CBV between cerebellum and frontal gray matter,cerebellum and temporal gray matter,cerebellum and occipital gray matter,and cerebellum and parietal gray matter(P=0.003,0.001,0.001,0.000.);There was a statistically significant difference in CBF between cerebell

关 键 词：X线计算机体层摄影 灌注 成年人 

分 类 号：R814[医药卫生—影像医学与核医学]