小儿难治性炎症性肠病的临床特点及沙利度胺治疗效果分析  

Clinical Characteristics of Refractory Inflammatory Bowel Disease in Children and Analysis ofTreatment Effects of Thalidomide

作　　者：严海燕 李小芹 YAN Hai-yan;LI Xiao-qin(Department of Gastroenterology,Henan children's Hospital(Children's Hospital Affiliated to Zhengzhou University/Children's Hospital of Zhengzhou),Zhengzhou 450053,Henan Province,China)

机构地区：[1]河南省儿童医院(郑州大学附属儿童医院/郑州儿童医院)消化科,河南郑州450053

出　　处：《罕少疾病杂志》2021年第3期84-85,共2页Journal of Rare and Uncommon Diseases

基　　金：河南省医学科技公关计划项目(201503234)。

摘　　要：目的探究小儿难治性炎症性肠病(IBD)的临床特点及沙利度胺(THD)治疗效果。方法回顾性分析我院收治的40例小儿难治性IBD患儿临床资料,对一般情况(性别、年龄、居住区域)、疾病类型[溃疡性结肠炎(UC)、克罗恩病(CD)]、病变部位(直肠、升结肠、回肠末端、左半结肠、右半结肠、全结肠)作出分析。根据随机数表法将患儿分为观察组与对照组均20例,对照组患儿使用硫唑嘌呤(AZA)治疗,观察组在对照组基础上加用THD。对比治疗2个月后两组临床疗效及治疗2个月内用药不良反应差异。结果难治性IBD患儿以男性为主,占比为72.50%;以10~14岁年龄段居多,占比57.50%;居住区域以农村居多,占比70.00%;疾病类型以UC较多、占比65.00%;病变部位多出现于全结肠,占比45.00%。治疗2个月后,观察组治疗有效率明显高于对照组(P<0.05);治疗2个月内,两组患儿不良反应发生率无明显差异(P>0.05)。结论小儿难治性IBD临床特点多样,予以THD与AZA联合治疗可较单用AZA取得更好疗效,安全性良好,适宜临床推广。Objective To explore the clinical characteristics of refractory inflammatory bowel disease(IBD)in children and the therapeutic effect of thalidomide(THD).Methods The clinical data of 40 children patients with refractory IBD admitted to our hospital were retrospectively analyzed.The general conditions(gender,age,residential area),disease types[ulcerative colitis(UC),Crohn's disease(CD)]and lesion sites(rectum,ascending colon,terminal ileum,left hemicolon,right hemicolon,whole colon)were analyzed.According to the random number table method,the patients were divided into observation and control groups,with 20 cases in each group.The control group was treated with azathioprine(AZA),and the observation group was added with THD based on the control group.After 2 months of treatment and adverse drug reactions within 2 months after treatment,the clinical efficacy was compared between the two groups.Results Children patients with refractory IBD were predominantly males,accounting for 72.50%.The majority were in the age group of 10-14 years,accounting for 57.50%.The residential areas were mostly countrysides,accounting for 70.00%.The disease type was mainly UC,accounting for 65.00%.The lesions mostly appeared in the whole colon,accounting for 45.00%.After 2 months of treatment,the effective rate of treatment in the observation group was significantly higher than that in the control group(P<0.05).Within 2 months of treatment,there were no significant differences in the incidence rates of adverse reactions between the two groups(P>0.05).Conclusion The clinical characteristics of refractory IBD in children are diverse.Combined treatment with THD and AZA can achieve better efficacy than AZA alone,with good safety and suitable for clinical promotion.

关 键 词：小儿 难治性炎症性肠病 沙利度胺 临床特点 治疗效果 

分 类 号：R516.1[医药卫生—内科学]