Amelioration of metabolic disorders by a mushroom-derived polyphenols correlates with the reduction of Ruminococcaceae in gut of DIO mice  

作　　者：Li Sun Li Bao Dorji Phurbu Shanshan Qiao Shanshan Sun Yangzom Perma Hongwei Liu 

机构地区：[1]State Key Laboratory of Mycology,Institute of Microbiology,Chinese Academy of Sciences,Beijing 100864,China [2]Savaid Medicine School,University of Chinese Academy of Sciences,Beijing 100864,China [3]Beijing Shijitan Hospital,Capital Medicinal University,Beijing 100864,China [4]Tibet Plateau Institute of Biology,Lhasa 850000,China [5]School of Life Sciences,University of Science and Technology of China,Hefei 230026,China

出　　处：《Food Science and Human Wellness》2021年第4期442-451,共10页食品科学与人类健康（英文）

基　　金：This study was supported by the Project of Science and Technology Department of Tibet(XZ201901-GB-19).

摘　　要：A polyphenolic alkaloid-enriched extract(PAE)was prepared from the fruiting bodies of a wild edible mushroom Sarcodon leucopus.Oral administration of PAE reduced hyperglycemia,hyperlipidemia,hepatic steatosis,and LPS-related infl ammation in high fat diet-induced obese(DIO)mice.Furthermore,we show that PAE produces taxonomic and predicted functional changes in the gut microbiome of DIO mice.A signifi cant decrease in the family of Ruminococcaceae,especially the secondary bile acid-producing bacteria of Intestinimonas and Anaerotruncus,is detected in the gut microbiome of PAE-treate mice.Accordingly,reductions of deoxycholic acid and lithocholic acid are found in the feces of PAE-treated DIO mice,which benefi ts for the intestinal integrity and the reduction of infl ammation.A gut microbiota related mechanism for the anti-metabolic syndrome effects of the PAE is proposed.We suppose the polyphenolic alkaloid extract from S.leucopus be a new and benefi cial prebiotic regulating glucose and lipid metabolisms.

关 键 词：Sarcodon leucopus Polyphenolic alkaloids Metabolic syndrome Gut microbiota Ruminococcaceae 

分 类 号：TS219[轻工技术与工程—粮食、油脂及植物蛋白工程]