178例川崎病患者的临床用药分析  

Analysis of medication in 178 patients with Kawasaki disease

作　　者：米洁[1] 成华[1] 郭焕利[1] 李媛[1] 李洋[1] 刘家华[1] MI Jie;CHENG Hua;GUO Huan-li;LI Yuan;LI Yang;LIU Jia-hua(Xi'an Children's Hospital,Xi'an 710003,China)

机构地区：[1]西安市儿童医院,陕西西安710003

出　　处：《中国药物应用与监测》2021年第2期124-127,共4页Chinese Journal of Drug Application and Monitoring

摘　　要：目的:了解川崎病患者的临床用药特点和规律,促进临床合理用药。方法:采用回顾性研究的方法,提取我院2019年10月^(-1)2月诊断为川崎病的住院患者病历信息,共计178例,对其临床用药情况进行统计分析。结果:丙种球蛋白不同给药时机下(早期、常规、晚期)三组间无统计学差异(P>0.05);丙种球蛋白不同给药方式(1 g·kg^(-1)·d^(-1),2 d;2 g·kg^(-1)·d^(-1),1 d)下患者体温恢复正常情况两组间无统计学差异(P>0.05)。急性期阿司匹林不同给药剂量下(80~120 mg·kg^(-1)·d^(-1)、30~50 mg·kg^(-1)·d^(-1)、<30 mg·kg^(-1)·d^(-1))三组患者体温恢复情况无统计学差异(P>0.05)。丙种球蛋白无反应患者采用激素冲击治疗24 h的退热比例(76.9%)高于再次给予丙种球蛋白治疗组(39.3%),差异具有统计学意义(P<0.05)。结论:川崎病患者应尽早给予丙种球蛋白治疗,给药方式推荐2 g·kg^(-1)·d^(-1),1 d,考虑一次性输注的不良反应可分2 d给药。急性期阿司匹林剂量推荐30~50 mg·kg^(-1)·d^(-1)或更低。考虑到退热效果和经济性,丙种球蛋白无反应患者首推激素治疗。Objective:To understand the characteristics and regularities of clinical medication in patients with Kawasaki disease and promote the rational drug use.Methods:A total of 178 patients diagnosed with Kawasaki disease in our hospital from October 2019 to December 2019 were retrospectively selected,medication of them were analyzed and summarized.Results:There was no statistical difference among the three groups(P>0.05)under different administration time of gamma globulin(early,conventional and late);There was no significant difference in the body temperature recovery of patients with Kawasaki disease between two groups(P>0.05)under different administraion of gamma globulin(1 g·kg^(-1)·d^(-1),2 d;2 g·kg^(-1)·d^(-1),1 d).There was no significant difference in the recovery of body temperature among the three groups(80^(-1)20 mg·kg^(-1)·d^(-1),30-50 mg·kg^(-1)·d^(-1),<30 mg·kg^(-1)·d^(-1))under different doses of aspirin in acute stage(P>0.05).The antipyretic rate in 24 h of patients with no response to gamma globulin given impact therapy of hormone was 76.9%,which was higher than 39.3%in the gamma globulin group.Conclusion:Intravenous injection of gamma globulin should be given as soon as possible for patients with Kawasaki disease.The recommended regimen of gamma globulin was 2 g·kg^(-1)·d^(-1) for 1 d,which also could be given in two days for patients who might develop adverse reaction to one-time infusion.The recommended dose of aspirin in acute stage was 30-50 mg·kg^(-1)·d^(-1) or lower.Considering the antipyretic effect and economy,hormone therapy was recommended as the first choice for patients with no response to gamma globulin.

关 键 词：川崎病 丙种球蛋白 阿司匹林 激素 

分 类 号：R969.3[医药卫生—药理学]