慢性萎缩性胃炎中医证候分布与胃黏膜病理变化的相关性研究  

Study on The Relationship between Distribution of Traditional Chinese Medicine Syndromes and Gastric Mucosal Pathological Changes in Chronic Atrophic Gastritis

作　　者：王少丽[1] 白宇宁[1] 倪媛元 姬航宇[1] 陈亚光[1] 刘震[1] WANG Shao-li;BAI Yu-ning;NI Yuan-yuan;JI Hang-yu;CHEN Ya-guang;LIU Zhen(Guang’anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China)

机构地区：[1]中国中医科学院广安门医院,北京100053

出　　处：《中国中医基础医学杂志》2021年第4期603-607,共5页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：首都卫生发展科研专项(首发2020-2-4152)-健脾通络解毒法干预慢性萎缩性胃炎的长期临床疗效评价研究;中国中医科学院广安门医院国家中医临床研究示范基地科研专项暨所级科研基金课题(2019S445)-基于真实世界中医药干预慢性萎缩性胃炎用药规律及方案优化研究;第六批全国老中医药专家学术经验继承项目。

摘　　要：目的:探讨慢性萎缩性胃炎(chronic atrophic gastritis,CAG)中医证候分布与胃黏膜病理变化的相关性。方法:采用横断面研究方法,收集就诊于中国中医科学院广安门医院402例CAG患者的一般资料、中医证候及胃黏膜病理变化等信息资料,通过描述性统计、卡方检验及Logistic回归分析等统计方法,分析患者的中医证候分布规律及与胃黏膜病理变化的相关性。结果:CAG中医证型分布频次由高至低依次为脾胃虚弱证、肝胃气滞证、脾胃湿热证、胃络瘀阻证、肝胃郁热证和胃阴不足证,胃络瘀阻证与腺体发生萎缩和肠上皮化生呈正相关[OR=1.814,P=0.005;OR=2.112,P=0.041),脾胃虚弱证、胃络瘀阻证与黏膜发生异型增生呈正相关(OR=3.118,P<0.001;OR=5.487,P<0.001)。结论:CAG中医证候多为复合证型,中医证型与胃黏膜病理变化间存在相关性。Objective:To explore the relationship between distribution of traditional Chinese medicine(TCM)syndromes and gastric mucosal pathological changes in chronic atrophic gastritis(CAG).Methods:In this study a crosssectional design was performed in Guang'anmen Hospital,China academy of Chinese mediead sciences involving 402 CAG patients to collect the data of general data,TCM syndromes and gastric mucosal pathological changes.And the statistical methods of descriptive statistics,chi square test and logistic regression analysis were used to analyze the distribution of TCM syndromes and the correlation with pathological changes of gastric mucosa.Results:The frequency of TCM syndrome types in CAG patients from high to low was as follows:syndrome of spleen and stomach weakness,syndrome of liver and stomach Qi stagnation,syndrome of spleen and stomach dampness heat,syndrome of stomach collaterals stasis,syndrome of liver and stomach stasis heat and syndrome of stomach yin deficiency.It showed that the syndrome of stomach collaterals stasis was positively correlated with atrophy of gastric mucosal glands and intestinal metaplasia(OR=1.814,P=0.005;OR=2.112,P=0.041),and the syndrome of spleen and stomach weakness and stomach collaterals stasis were positively correlated with dysplasia of gastric mucosa(OR=3.118,P<0.001;OR=5.487,P<0.001).Conclusion:The TCM syndromes in CAG were mostly complex syndromes,and there was a certain correlation between pathological changes of gastric mucosa and TCM syndromes.

关 键 词：慢性萎缩性胃炎 证候 胃黏膜病理 相关性 

分 类 号：R256.3[医药卫生—中医内科学]