定量乙型肝炎e抗原对乙型肝炎表面抗原阳性孕妇乙型肝炎病毒脱氧核糖核酸高载量的筛检价值  

Value of HBeAg quantification on screening of HBV DNA high viral load in HBsAg positive pregnant women

作　　者：丰淑英 李雁笛 张改萍[1] 赵甜静 冯永亮[2] 王素萍[2] Feng Shuying;Li Yandi;Zhang Gaiping;Zhao Tionjing;Feng-yongliang;Wang Suping(Department of Obstetrics and Gynecology,Taiyuan Third Municipal People's Hospital,Shanxi 030001,China;不详)

机构地区：[1]太原市第三人民医院妇产科,030001 [2]山西医科大学公共卫生学院

出　　处：《中国药物与临床》2021年第7期1061-1063,共3页Chinese Remedies & Clinics

基　　金：国家自然科学基金(81573212)。

摘　　要：目的探讨定量检测HBeAg是否可以作为HBsAg阳性孕妇HBV DNA的替代指标。方法入组2011年6月至2013年7月在太原市第三人民医院分娩的HBsAg阳性孕妇及其新生儿399对。分别应用化学发光免疫试验与实时荧光定量PCR检测HBeAg与HBV DNA。采用SAS软件与Medcalc软件进行统计分析。结果孕妇HBeAg预测其HBV DNA≥2×10^(5)U/ml的最佳截断值为21.29 S/CO,阳性预测值为78.18%,阴性预测值为97.83%。HBsAg阳性孕妇HBV DNA≥2×10^(5)U/ml时,其新生儿更易发生HBV宫内传播(P=0.008),当HBsAg阳性孕妇HBeAg≥21.29 S/CO时,其新生儿发生HBV宫内传播的风险增加(P<0.01)。结论 HBsAg阳性孕妇定量HBeAg在一定程度上可以作为HBV DNA高载量(≥2×10^(5)IU/ml)的替代指标。Objective To investigate whether quantification of hepatitis B e antigen(HBeAg)can be used as a surrogate indicator for HBV DNA in HBsAg-positive pregnant women.Methods Included in this study were a total of 399 pairs of HBsAg-positive pregnant women and their newborns in the Department of Obstetrics and Gynecology,Taiyuan Third Municipal People′s Hospital between June 2011 and July 2013.HBeAg was examined by chemiluminescence immunoassay,and HBV DNA by real-time fluorescence quantitative polymerase chain reaction,respectively.SAS software and Medcalc software were used for statistical analysis.Results The optimal cut-off value for HBeAg in predicting HBV DNA≥2×10^(5) U/ml was 21.29 S/CO,with a positive predictive value of 78.18%,and a negative predictive value of 97.83%.The newborns of HBsAg-positive pregnant women with HBV DNA≥2×10^(5) U/ml were more likely to have intrauterine HBV transmission(P=0.008).The newborns of HBsAg-positive pregnant women with HbeAg≥21.29 S/CO had increased risk of intrauterine HBV transmission(P<0.01).Conclusion HBeAg quantification may somehow be used as a surrogate indicator of HBV DNA high load(≥2×10^(5) U/ml)in HBsAg-positive pregnant women.

关 键 词：乙型肝炎表面抗原 乙型肝炎E抗原 乙型肝炎病毒脱氧核糖核酸 宫内传播 

分 类 号：R714.251[医药卫生—妇产科学]