布鲁菌病临床特征分析  

Analysis of clinical characteristics of brucellosis

作　　者：田岳飏[1] 高会霞[1] 孙倩 李砚峰 张志[1] TIAN Yueyang;GAO Huixia;SUN Qian;LI Yanfeng;ZHANG Zhi(Department of Laboratory Medicine,the Fifth Hospital of Shijiazhuang City,Hebei Province,Shijiazhuang 050021,China)

机构地区：[1]石家庄市第五医院检验科,河北石家庄050021

出　　处：《中国医药导报》2021年第13期89-92,共4页China Medical Herald

基　　金：河北省医学科学研究重点课题(20191451)。

摘　　要：目的分析石家庄市第五医院收集的219例布鲁菌病患者临床表现及实验室资料的差异,为布鲁菌病的防治提供科学依据。方法以2016年1月—2018年12月石家庄市第五医院收治的布鲁菌病患者共219例为研究对象,按不同年龄段分为<20岁、20~<40岁、40~60岁和>60岁组,四组例数分别为9、43、105和62例。比较四组CD3+T细胞、CD4+T细胞、CD8+T细胞、C反应蛋白(CRP)的异常率。比较四组各并发症发生情况。结果四组CD3+T细胞、CD4+T细胞、CRP异常率比较,差异有统计学意义(均P<0.05),CD8+T细胞异常率比较差异无统计学意义(P>0.05)。进一步两两比较发现,>60岁组CD3+T细胞异常率低于40~60岁组,40~60岁组CD4+T细胞异常率低于20~<40岁、>60岁组,20~<40岁组CRP异常率低于40~60岁、>60岁组,差异均有统计学意义(均P<0.008)。四组肝脏疾病、睾丸炎、腰椎骨质增生和肺部感染比较,差异有统计学意义(均P<0.05),椎间盘突出和高血压发生率比较差异均无统计学意义(P>0.05)。进一步两两比较,>60岁组肝脏疾病、睾丸炎发生率均高于20~<40岁、40~60岁组,腰椎骨质增发生率高于<20岁、20~<40岁、40~60岁组,20~<40岁、40~60岁组肺部感染发生率低于<20岁组,差异均有统计学意义(均P<0.008)。结论T细胞亚群的检测结果可以为判断布鲁菌病患者的免疫状况提供依据,CRP值可作为一项判断布鲁菌病患者机体炎症严重程度的辅助指标。Objective To analyze the differences in clinical manifestations and laboratory data of 219 patients with brucellosis collected in the Fifth Hospital of Shijiazhuang City,and to provide the scientific basis for the prevention and treatment of brucellosis.Methods A total of 219 patients with brucellosis admitted to the Fifth Hospital of Shijiazhuang City from January 2016 to December 2018 were collected as the research objects.According to different age groups,they were divided into<20 years old,20-<40 years old,40-60 years old and>60 years old groups.The number of patients in the four groups was 9,43,105 and 62,respectively.The abnormal rates of CD3+T cells,CD4+T cells,CD8+T cells and CRP in four groups were compared.The incidence of complications in four groups was compared.Results There were statistically significant differences in the abnormal rates of CD3+T cells,CD4+T cells and C reactive protein(CRP)among the four groups(all P<0.05),while there were no statistically significant differences in the abnormal rates of CD8+T cells among the four groups(P>0.05).Further pair comparison showed that the abnormal rate of CD3+T cells in>60 years old group was lower than that in 40-60 years old group,and the abnormal rate of CD4+T cells in 40-60 years group was lower than that in 20-<40 years old and>60 years old group,and the abnormal rate of CRP in 20-<40 years old group was lower than that in 40-60 years old group and>60 years old group,and the differences were all statistically significant(all P<0.008).There were statistically significant differences in liver diseases,orchitis,lumbar osteogeny and pulmonary infection among the four groups(all P<0.05).There was no significant difference in the incidence of disc herniation and hypertension among the four groups(P>0.05).Further pair comparison showed that the incidence of liver disease and orchitis in>60 years old group was higher than that in 20-<40 years old group and 40-60 years old group and the incidence of lumbar osteopenia was higher than that in<20 years old gr

关 键 词：布鲁氏菌 布鲁菌病 临床表现 T细胞亚群 C反应蛋白 

分 类 号：R516.7[医药卫生—内科学]