1号中药洗剂对肛周脓肿术后创面愈合疗效及血清炎症因子的影响  

Effect of No.1 traditional Chinese medicine lotion on wound healing and serum inflammatory factors after perianal abscess operation

作　　者：张朝阳 梁靖华 孙林梅 李璞 费友 ZHANG Chaoyang;LIANG Jinghua;SUN Linmei;LI Pu;FEI You(Graduate School,Shaanxi University of Chinese Medicine,Shaanxi Province,Xianyang 712000,China;Department of Anorectal,Shenzhen Anorectal Hospital of Traditional Chinese Medicine,Guangdong Province,Shenzhen 518000,China;Department of Anorectal,Xi’an Hospital of Traditional Chinese Medicine,Shaanxi Province,Xi’an 710000,China)

机构地区：[1]陕西中医药大学研究生院,陕西咸阳712000 [2]深圳市中医肛肠医院肛肠科,广东深圳518000 [3]西安市中医医院肛肠科,陕西西安710000

出　　处：《中国医药导报》2021年第13期121-124,共4页China Medical Herald

基　　金：陕西省中医管理局中医药科研课题(LCPT107、LCPT062)。

摘　　要：目的观察1号中药洗剂对肛周脓肿术后创面愈合疗效及血清炎症因子的影响。方法选取2018年2月—6月于深圳市中医肛肠医院肛肠科住院的肛周脓肿术后患者84例,采用随机数字表法分为对照组和观察组,每组42例。两组术后给予注射用头孢他啶3 d,同时对照组给予高锰酸钾洗剂坐浴,观察组给予1号中药洗剂坐浴,术后两组均给予相同的补液、调整酸碱平衡药物,对症支持治疗。比较两组临床疗效、创面愈合时间、创面水肿消失时间、视觉模拟评分(VAS)、血清炎症因子水平。结果两组临床疗效比较,差异无统计意义(P>0.05)。观察组创面愈合时间和创面水肿消失时间均短于对照组,差异有统计学意义(P<0.05)。VAS组间比较、时间点比较及交互作用差异均有统计学意义(P<0.05);两组不同时间点VAS比较,差异有统计学意义(P<0.05)。两组术后10 d的白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平均低于术后1 d,差异有统计学意义(P<0.05);观察组术后1 d和术后10 d的IL-6、TNF-α水平均低于对照组,差异有统计学意义(P<0.05)。结论1号中药洗剂可以明显改善肛周脓肿患者术后创面愈合情况,减轻患者痛苦,促进创面愈合,降低血清炎症因子水平,减少术后再次感染风险,值得临床推广。Objective To observe the effect of No.1 traditional Chinese medicine lotion on wound healing and serum inflammatory factors after perianal abscess operation.Methods Eighty-four patients with perianal abscess in Department of Anorectal,Shenzhen Anorectal Hospital of Traditional Chinese Medicine from February to June 2018 were selected and divided into control group and observation group according to random number table method,42 cases in each group.Two groups were given Ceftazidime for injection for three days after operation,while control group was given potassium permanganate lotion hip bath,and observation group was given No.1 traditional Chinese medicine lotion hip bath.Two groups were given the same rehydration,acid-base balance adjustment drugs,symptomatic support treatment after operation.Clinical efficacy,wound healing time,wound edema disappearance time,visual analogue scale(VAS)and serum inflammatory factors were compared between two groups.Results There was no significant difference in clinical efficacy between two groups(P>0.05).The wound healing time and wound edema disappearance time of observation group were shorter than those of control group,and the difference was statistically significant(P<0.05).There were significant differences in VAS on group comparison,time point comparison and interaction(P<0.05).There was significant difference in VAS between two groups at different time points(P<0.05).The levels of interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in two groups at 10 days after operation were lower than those at one day after operation,and the differences were statistically significant(P<0.05).The levels of IL-6 and TNF-αin observation group at one day and 10 days after operation were lower than those in control group(P<0.05).Conclusion No.1 traditional Chinese medicine lotion can significantly improve the wound healing of patients with perianal abscess,reduce the pain of patients,promote wound healing,reduce the level of serum inflammatory factors,and reduce the risk of postoperati

关 键 词：肛周脓肿 熏洗 中药 临床观察 

分 类 号：R266[医药卫生—中医外科学]