不同嗜酸性粒细胞计数的慢性阻塞性肺疾病患者临床特征与中医证型分布规律  

Clinical characteristics and TCM syndromes distribution of different EOS count in COPD patients

作　　者：刘宏祥[1] 史曼[2] 赵永辰[1] 周胜男 张彦广[4] 高宏伟 孙艳敏 LIU Hong-xiang;SHI Man;ZHAO Yong-chen;ZHOU Sheng-nan;ZHANG Yan-guang;GAO Hong-wei;SUN Yan-min(Department of Integrated Traditional Chinese and Western Medicine,Afiliated Hospital of Hebei University,Baoding 071000,China;Department of Cardiology.Afliated Hospital of Hebei University,Baoding 07000 China;Deparment of Internal Medicine,Hebei Rongjun Hospital,Baoding 071000.China;Department of Integrated Traditional Chinese and Westem Medicine,Baoding Seventh Hospital,Baoding 072150.China;Hebei Rongcheng County Traditional Chinese Medicine Hospital,Rongcheng 071700,China)

机构地区：[1]河北大学附属医院中西医科,保定071000 [2]河北大学附属医院心内科,保定071000 [3]河北省荣军医院内科,保定071000 [4]保定市第七医院中西医结合科,保定072150 [5]容城县中医医院,河北容城071700

出　　处：《中华中医药杂志》2021年第4期2323-2326,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：河北省科技厅科技支撑项目(No.162777223);河北省财政厅专科带头人培养项目(No.361007)。

摘　　要：目的:揭示外周血不同嗜酸性粒细胞(EOS)计数的慢性阻塞性肺疾病(COPD)患者的临床特征及中医证型分布规律。方法:回顾研究2016年1月1日至2018年12月31日河北大学附属医院出院第一诊断为COPD患者,分为EOS<2%组、2%≤EOS≤4%组、EOS>4%组,对比分析3组患者性别、年龄、吸烟史、病程、住院时间、肺功能、炎症指标、体质量及预后情况,同时对3组患者急性加重期及稳定期证型分布规律进行对比分析。结果:筛选出符合条件病例307例,EOS<2%组与2%≤EOS≤4%组、EOS>4%组过去1年内急性加重次数、过去1年住院次数存在显著差异(P<0.01),EOS>4%组过去1年内急性加重次数最多,过去1年住院次数最高。2%≤EOS≤4%组年龄高于EOS<2%组与EOS>4%组(P<0.05,P<0.01),2%≤EOS≤4%组病程长于EOS<2%组(P<0.01),EOS<2%组与2%≤EOS≤4%组BMI值高于EOS>4%组(P<0.01)。急性加重期及稳定期主要证型分别为外寒里饮证、脾肾阳虚证。结论:EOS增高型COPD患者易发生急性加重,EOS增高型COPD急性加重期主要证型为外寒里饮证,稳定期为脾肾阳虚证。Objective:To reveal the clinical characteristics and syndrome pattern of patients with COPD in different Eosinophilic granulocytes(EOS)count.Methods:The first diagnosis of COPD patients from the Affiliated Hospital of Hebei University from January 1,2016 to December 31,2018 was retrospectively analyzed.The patients were divided into EOS<2%group,2%≤EOS≤4%group,EOS>4%group,compared and analyzed the three groups of patients sex,age,smoking,course of illness,length of hospitalization,lung function,inflammatory indicators,body weight and prognosis,At the same time,the distribution law of acute exacerbation period and stable period syndrome in three groups of patients was compared and analyzed.Results:A total of 307 eligible cases were screened.The number of acute exacerbations,and the number of hospitalizations in the past year in EOS<2%and 2%≤EOS≤4%,EOS>4%,existed statistical differences,(P<0.01)EOS>4%increased the most of times in the past year,and the highest number of hospitalizations in the past year.The age of 2%≤EOS≤4%group was older than the other two groups,the course of 2%≤EOS≤4%group was longer than EOS<2%group(P<0.01),the BMI value of EOS<2%and 2%≤EOS≤4%group was higher than the EOS>4%group(P<0.01).The main syndromes of acute exacerbation period and stable period were external cold and internal drinking syndrome,and spleen and kidney yang deficiency syndrome,respectively.Conclusion:Acute exacerbations are more likely to occur in patients with elevated EOS type COPD.The main syndrome in the acute exacerbation period is external cold and internal drinking syndrome,and the stable period is the spleen kidney yang deficiency syndrome.

关 键 词：慢性阻塞性肺疾病 嗜酸性粒细胞 临床特征 中医证型 回顾性分析 

分 类 号：R259[医药卫生—中西医结合]